3,5-二羟基苯甲酸甲酯合成路线 （共 124 条）
反应条件
1: 78 percent / K2CO3 / dimethylformamide / 48 h / 60 °C 2: 98 percent / hydrogen / platinum(IV) oxide / tetrahydrofuran / 103.43 Torr View Scheme
参考文献
Wright, Michael E.; Fallis, Stephen; Guenthner, Andy J.; Baldwin, Lawrence C.
Macromolecules, 2005 , vol. 38, # 24 p. 10014 - 10021
反应条件
1: 96 percent / K2CO3 / acetone / 12 h / Heating 2: 97 percent / LiAlH4 3: 84 percent / Et3N / CH2Cl2 / 0.33 h / 4 °C 4: 69 percent / benzyltriethylammonium chloride / H2O; CHCl3 / 2 h / Heating 5: 92 percent / aq. Ba(OH)2 / dioxane / 15 h / 115 °C View Scheme
参考文献
Meltzer, Peter C.; Dalzell, Haldean C.; Razdan, Raj K.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 2825 - 2829
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 12 h;
参考文献
Loim; Kelbyscheva
Russian Chemical Bulletin, 2004 , vol. 53, # 9 p. 2080 - 2085
反应条件
1: K2CO3 / acetone / 20 h / Heating 2: 90 percent / 10percent aq. NaOH / acetone / 2 h / Heating 3: 65 percent / SOCl2 / benzene / 5 h / Heating 4: 77 percent / (Et)3N / CH2Cl2 / 1.) 0 deg C, 2 h, 2.) RT, overnight 5: 96 percent / 47percent HBr / methanol; CHCl3 / 0.17 h / -10 °C View Scheme
参考文献
Szirmai; Odqvist; Halldin
Journal of Labelled Compounds and Radiopharmaceuticals, 1996 , vol. 38, # 4 p. 309 - 324
反应条件
1: potassium carbonate / acetonitrile / 20 °C 2: sodium hydroxide / 1,4-dioxane / 5 h / 20 °C 3: triethylamine; diphenyl phosphoryl azide / 80 °C View Scheme
参考文献
Song, Yu Min; Ha, Young Mi; Kim, Jin-Ah; Chung, Ki Wung; Uehara, Yohei; Lee, Kyung Jin; Chun, Pusoon; Byun, Youngjoo; Chung, Hae Young; Moon, Hyung Ryong
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 24 p. 7451 - 7455
反应条件
hydrazine hydrate in ethanol 12 h; Reflux;
参考文献
Frlan, Rok; Kovas, Andreja; Blanot, Didier; Gobec, Stanislav; Pecar, Slavko; Obreza, Ales
Acta Chimica Slovenica, 2011 , vol. 58, # 2 p. 295 - 310
反应条件
potassium carbonate in acetone Benzylation; 5 h; Heating;
参考文献
Maekelae, Taru; Matikainen, Jorma; Waehaelae, Kristiina; Hase, Tapio
Tetrahedron, 2000 , vol. 56, # 13 p. 1873 - 1882
反应条件
1: 3,5-dihydroxybenzoic acid methyl ester With sodium hydride in N,N-dimethyl-formamide; mineral oil T=0°C; Inert atmosphere; 2: benzyl bromide in N,N-dimethyl-formamide; mineral oil T=20°C; 2 h;
参考文献
THE UNIVERSITY OF SIDNEY; DUKE, Colin Charles; TRAN, Van Hoan; DUKE, Rujee Kyokajee
Patent: WO2012/149608 A1, 2012 ;
Location in patent: Page/Page column 34 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=80°C; 25 h;
参考文献
Gunter, Maxwell J.; Johnston, Martin R.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 8 p. 995 - 1008
反应条件
potassium carbonate in acetone T=20°C; 24 h;
参考文献
Denmark, Scott E.; Kobayashi, Tetsuya; Regens, Christopher S.
Tetrahedron, 2010 , vol. 66, # 26 p. 4745 - 4759
