3,5-二羟基苯甲酸甲酯合成路线 （共 124 条）
反应条件
hydrogenchloride in dichloromethane 18 h;
参考文献
Pyun, Jeffrey; Rees, Ian; Frechet, Jean M.J.; Hawker, Craig J.
Australian Journal of Chemistry, 2003 , vol. 56, # 8 p. 775 - 782
反应条件
iodine; sodium hydrogencarbonate in tetrahydrofuran; water T=2 - 8°C; 1.5 h; Large scale reaction;
参考文献
Berliner, Martin A.; Cordi, Eric M.; Dunetz, Joshua R.; Price, Kristin E.
Organic Process Research and Development, 2010 , vol. 14, # 1 p. 180 - 187
反应条件
1: 83 percent / K2CO3 / acetone / 48 h / Heating 2: 92 percent / LiAlH4 / tetrahydrofuran / 1 h / 0 °C 3: 91 percent / NaOAc; pyridinium chlorochromate / CH2Cl2 / 2 h / 0 °C View Scheme
参考文献
Aratani, Naoki; Takagi, Akihiko; Yanagawa, Yoshiki; Matsumoto, Takuya; Kawai, Tomoji; Yoon, Zin Seok; Kim, Dongho; Osuka, Atsuhiro
Chemistry - A European Journal, 2005 , vol. 11, # 11 p. 3389 - 3404
反应条件
1: 100 percent / K2CO3 / acetonitrile / 100 °C 2: 92 percent / KOH / ethanol / 4 h / Heating View Scheme
参考文献
Pickaert, Guillaume; Cesario, Michele; Ziessel, Raymond
Journal of Organic Chemistry, 2004 , vol. 69, # 16 p. 5335 - 5341
反应条件
1: 80 percent / potassium iodide; potassium carbonate; [18]crown-6 / acetone / 12 h / Heating 2: 98 percent / LiAlH4 / tetrahydrofuran / 6.5 h / 0 - 20 °C 3: 88 percent / carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 1 h / 20 °C 4: 85 percent / potassium iodide; potassium carbonate; [18]crown-6 / acetone / 10 h / Heating 5: 94 percent / LiAlH / tetrahydrofuran / 0 - 20 °C 6: 83 percent / carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 20 °C View Scheme
参考文献
Freeman; Chrisstoffels; Frechet
Journal of Organic Chemistry, 2000 , vol. 65, # 22 p. 7612 - 7617
反应条件
1: 96 percent / K2CO3 / dimethylformamide / 8 h / 75 °C 2: 92 percent / LiAlH4 / tetrahydrofuran / 0 - 20 °C 3: pyridinium chlorochromate / CH2Cl2 / 20 °C View Scheme
参考文献
Zhuravel, Michael A.; Davis, Nicolynn E.; Nguyen, SonBinh T.; Koltover, Ilya
Journal of the American Chemical Society, 2004 , vol. 126, # 32 p. 9882 - 9883
反应条件
1: 95 percent / K2CO3 / acetone / 4.5 h / Heating 2: 97 percent / Red-al / toluene / 4 h / Heating 3: 97 percent / Et3N / CH2Cl2 / 1.75 h / 0 °C 4: 93 percent / 2-methoxy-ethanol / 17 h / 24 °C 5: 97 percent / KOH / ethanol / 18 h / Heating 6: 96 percent / HCl / 16.5 h View Scheme
参考文献
Meltzer, Peter C.; Dalzell, Haldean C.; Razdan, Raj K.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 2825 - 2829
反应条件
potassium carbonate in isobutyramide T=85°C; 5 h;
参考文献
US2010/36081 A1, ;
Page/Page column 7-8 ;
反应条件
1: 64 percent / K2CO3 / dimethylformamide / 16 h / 40 °C 2: 95 percent / Tesser's base / 4.5 h / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 10 p. 1903 - 1915
反应条件
1: 80 percent / potassium iodide; potassium carbonate; [18]crown-6 / acetone / 12 h / Heating 2: 98 percent / LiAlH4 / tetrahydrofuran / 6.5 h / 0 - 20 °C 3: 88 percent / carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Freeman; Chrisstoffels; Frechet
Journal of Organic Chemistry, 2000 , vol. 65, # 22 p. 7612 - 7617
