3,5-二羟基苯甲酸甲酯合成路线 （共 124 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 18 h;
参考文献
Iwata, Hidehisa; Kohara, Yasuhisa; Cao, Sheldon X.; Guntupalli, Prasuna; Gwaltney, Stephen L.; Hosfield, David J.; Liu, Yan; Stafford, Jeffrey A.; Throop, Beverly
Patent: US2010/69431 A1, 2010 ;
Location in patent: Page/Page column 104 ;
反应条件
1: K2CO3 2: NaOH / methanol View Scheme
参考文献
LeMahieu; Carson; Han; Madison; Hope; Chen; Morgan; Hendrickson
Journal of Medicinal Chemistry, 1993 , vol. 36, # 20 p. 3029 - 3031
反应条件
1: 95 percent / K2CO3 / acetonitrile / 100 °C 2: 94 percent / KOH / ethanol / 4 h / Heating 3: 100 percent / SOCl2 / Heating View Scheme
参考文献
Ili, Monica; Bucos, Madalina; Dumitracu, Florea; Circu, Viorel
Journal of Molecular Structure, 2011 , vol. 987, # 1-3 p. 1 - 6
反应条件
sodium hydride in N,N-dimethyl-formamide; mineral oil
T=0 - 20°C; 2.33333 h; Inert atmosphere;
参考文献
Koolaji, Nooshin; Abu-Mellal, Abdallah; Tran, Van H.; Duke, Rujee K.; Duke, Colin C.
European Journal of Medicinal Chemistry, 2013 , vol. 63, p. 415 - 422
反应条件
tetra-(n-butyl)ammonium iodide; potassium carbonate in acetone
3 h; Heating;
参考文献
Chakraborty; Reddy
Journal of Organic Chemistry, 1992 , vol. 57, # 20 p. 5462 - 5469
反应条件
sulfuric acid
4 h; Reflux;
参考文献
MSD OSS B.V.; HUISMAN, Ines; VAN DER STELT, Marcelis; WIEDENHOF, Wouter; BAKER-GLENN, Charles, Anthony, Graham; BLACKABY, Wesley, Peter; TRIVEDI, Naimisha
Patent: WO2013/41457 A1, 2013 ;
Location in patent: Page/Page column 19-20 ;
参考文献
SmithKline Beecham Corporation
Patent: US5998470 A1, 1999 ;
US 5998470 A
反应条件
potassium carbonate in acetone
18 h; Heating;
参考文献
Crombie, Leslie; Jamieson, Sally V.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1467 - 1476
反应条件
1: 96 percent / potassium carbonate / dimethylformamide / 60 °C
2: 99 percent / LiAlH4 / tetrahydrofuran / 3 h
View Scheme
参考文献
Elmer, Stephanie L.; Zimmerman, Steven C.
Journal of Organic Chemistry, 2004 , vol. 69, # 21 p. 7363 - 7366
反应条件
1: 96 percent / K2CO3 / acetone
2: 98 percent / LiAlH4 / diethyl ether
3: 84 percent / NEt3 / CH2Cl2
4: 69 percent / BzNEt3Cl / CHCl3; H2O
5: 92 percent / Ba(OH)2 / dioxane; H2O
6: diethyl ether
7: 99 percent / 60percent HClO4 / H2O; acetic acid
8: 97 percent / H2 / Pd/C (5percent) / ethyl acetate; ethanol
9: CH3ONa / methanol
View Scheme
参考文献
Ichinose, Koji; Ebizuka, Yutaka; Sankawa, Ushio
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 10 p. 2873 - 2875
