2,6-二羟基苯甲酸甲酯合成路线 （共 30 条）
反应条件
thionyl chloride T=0°C; RefluxInert atmosphere;
参考文献
Carta, Fabrizio; Vullo, Daniela; Maresca, Alfonso; Scozzafava, Andrea; Supuran, Claudiu T.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 6 p. 1564 - 1569
反应条件
ammonium hydroxide; silver nitrate in water T=0 - 20°C; 18.5 h;
参考文献
Neale, Jason R.; Richter, Natali B.; Merten, Kevyn E.; Grant Taylor; Singh, Sujan; Waite, Leonard C.; Emery, Nicole K.; Smith, Ned B.; Cai, Jian; Pierce Jr., William M.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 3 p. 680 - 683
反应条件
NaH; methyl iodide in dichloromethane; N,N-dimethyl-formamide
参考文献
SmithKline Beecham Corporation
Patent: US6204294 B1, 2001 ;
US 6204294 B1
反应条件
silica gel; toluene-4-sulfonic acid in water; toluene T=80°C; 6 h;
参考文献
Blay, Gonzalo; Cardona, M. Luz; Garcia, M. Begona; Pedro, Jose R.
Synthesis, 1989 , # 6 p. 438 - 439
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate 0.5 h;
参考文献
Ohzeki, Tomoya; Mori, Kenji
Bioscience, biotechnology, and biochemistry, 2003 , vol. 67, # 10 p. 2240 - 2244
反应条件
in tetrahydrofuran Ambient temperature;
参考文献
Nagata, Toshi
Bulletin of the Chemical Society of Japan, 1991 , vol. 64, # 10 p. 3005 - 3016
反应条件
1: aluminium chloride; benzene 2: hydrogen chloride View Scheme
参考文献
Journal fuer Praktische Chemie (Leipzig), , vol. <2> 124, p. 322
反应条件
1: glycerol / 135 °C 2: hydrogen chloride View Scheme
参考文献
Journal fuer Praktische Chemie (Leipzig), , vol. <2> 124, p. 322
参考文献
Journal of pharmaceutical sciences, , vol. 59, # 1 p. 67 - 71
反应条件
Heating; Product distribution;
参考文献
Journal of Heterocyclic Chemistry, , vol. 18, p. 667 - 670
