2,6-二羟基苯甲酸甲酯合成路线 （共 30 条）
反应条件
in diphenylether 6 h; Heating;
参考文献
Patel, G. N.; Trivedi, K. N.
Synthetic Communications, 1989 , vol. 19, # 9-10 p. 1641 - 1648
反应条件
1: 61 percent / K2CO3 / dimethylformamide / 1 h / 80 °C
2: 71 percent / diisobutylaluminum hydride / toluene / 1 h / 45 °C
3: 86 percent / pyridinium chlorochromate / CH2Cl2 / 1 h / Ambient temperature
View Scheme
参考文献
Shipchandler; Soine; Gupta
Journal of pharmaceutical sciences, 1970 , vol. 59, # 1 p. 67 - 71
反应条件
1: 48 percent / potassium carbonate; sodium iodide / dimethylformamide / 4.5 h / 0 - 20 °C
2: pyridine / 2 h / cooling
3: 1.55 g / potassium carbonate / tetrakis(triphenylphosphine)palladium(0) / benzene; ethanol / 14 h / Heating
View Scheme
参考文献
Ohzeki, Tomoya; Mori, Kenji
Bioscience, biotechnology, and biochemistry, 2003 , vol. 67, # 10 p. 2240 - 2244
反应条件
1.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide; acetonitrile / 14 h / 20 °C
2.1: sodium hydroxide / tetrahydrofuran; water / 24 h / 80 °C
2.2: pH 1 - 2
View Scheme
参考文献
Fan, Xing; Zhang, Feng-Hua; Al-Safi, Rasha I.; Zeng, Li-Fan; Shabaik, Yumna; Debnath, Bikash; Sanchez, Tino W.; Odde, Srinivas; Neamati, Nouri; Long, Ya-Qiu
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 16 p. 4935 - 4952
反应条件
sodium hydrogencarbonate in N,N-dimethyl-formamide
参考文献
SmithKline Beecham Corporation
Patent: US6204294 B1, 2001 ;
US 6204294 B1
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran
T=25°C;
参考文献
Bass, R. J.; Banks, B. J.; Snarey, M.
Tetrahedron Letters, 1980 , vol. 21, p. 769 - 770
反应条件
potassium carbonate; sodium iodide in N,N-dimethyl-formamide
T=0 - 20°C; 4.5 h;
参考文献
Ohzeki, Tomoya; Mori, Kenji
Bioscience, biotechnology, and biochemistry, 2003 , vol. 67, # 10 p. 2240 - 2244
参考文献
Eli Lilly and Company
Patent: US4416683 A1, 1983 ;
反应条件
in diphenylether
12 h; Heating;
参考文献
Patel G N; Trivedi K N
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1991 , vol. 30, # 4 p. 437 - 439
反应条件
in diphenylether
0.5 h; Heating;
参考文献
Patel G N; Trivedi K N
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1991 , vol. 30, # 4 p. 437 - 439
