2,4-二羟基苯甲酸甲酯合成路线 （共 80 条）
反应条件
1: 2,4-dihydroxybenzoic acid methyl ester With potassium carbonate in N,N-dimethyl-formamide T=20°C; 0.0833333 h; 2: p-methoxybenzyl chloride in N,N-dimethyl-formamide T=10 - 15°C;
参考文献
Tangdenpaisal, Kassrin; Sualek, Supannee; Ruchirawat, Somsak; Ploypradith, Poonsakdi
Tetrahedron, 2009 , vol. 65, # 22 p. 4316 - 4325
反应条件
tetrabutyl-ammonium chloride; potassium carbonate; potassium iodide in acetone Heating;
参考文献
Astles; Brown; Handscombe; Harper; Harris; Lewis; Lockey; McCarthy; McLay; Porter; Roach; Smith; Walsh
European Journal of Medicinal Chemistry, 1997 , vol. 32, # 5 p. 409 - 423
反应条件
1: boron fluoride; diethyl ether 2: aq. NaOH solution 3: quinoline; copper-powder View Scheme
参考文献
Nickl
Chemische Berichte, 1959 , vol. 92, p. 1989,1994
反应条件
1: 1.) K2CO3 / 1.) acetone, room temp., 1 h, 2.) acetone, reflux, 3.5 h 2: 91 percent / Br2 / CHCl3 / 1.5 h / Ambient temperature View Scheme
参考文献
Ishibashi, Fumito; Miyazaki, Yuka; Iwao, Masatomo
Tetrahedron, 1997 , vol. 53, # 17 p. 5951 - 5962
反应条件
1: nitrobenzene; aluminium chloride 2: aqueous hydrochloric acid; acetic acid / 185 °C View Scheme
参考文献
Sethna et al.
Journal of the Chemical Society, 1938 , p. 228,231
反应条件
1: 74 percent / K2CO3 / acetone / 25 h / Heating 2: 92 percent / 66 percent hydrazine hydrate / ethanol; H2O / 8 h / Heating View Scheme
参考文献
Beger, J.; Wagner, G.; Uhlig, E.; Dinjus, U.
Journal fuer Praktische Chemie (Leipzig), 1983 , vol. 325, # 5 p. 708 - 718
反应条件
1: 58 percent / K2CO3 / acetone 2: 96 percent / NaH / dimethylformamide View Scheme
参考文献
Astles; Brown; Handscombe; Harper; Harris; Lewis; Lockey; McCarthy; McLay; Porter; Roach; Smith; Walsh
European Journal of Medicinal Chemistry, 1997 , vol. 32, # 5 p. 409 - 423
反应条件
nitric acid; acetic anhydride in acetic acid T=0 - 22°C;
参考文献
Heretsch, Philipp; Giannis, Athanassios
Synthesis, 2007 , # 17 p. 2614 - 2616
参考文献
Parekh; Shah
Journal of the University of Bombay, Science: Physical Sciences, Mathematics, Biological Sciences and Medicine, 11, Tl 5 A <1943> 101
参考文献
Journal fuer Praktische Chemie (Leipzig), , vol. <2> 151, p. 145,151
