2,4-二羟基苯甲酸甲酯合成路线 （共 80 条）
反应条件
1: NEt3, DMAP / dimethylformamide
2: 1.) NaH / 1.) DMF
3: DOWEX 50X2 / methanol
4: 1.) NaH / 1.) DMF
5: aq. NaOH / 235 °C
6: 1.) NaH / 1.) DMF
View Scheme
参考文献
Patek; Lebl
Tetrahedron Letters, 1991 , vol. 32, # 31 p. 3891 - 3894
反应条件
sulfuryl dichloride in dichloromethane
T=0 - 25°C; 19 h;
参考文献
Blagg, Brian; Shen, Gang; Clevenger, Randell C.
Patent: US2006/89495 A1, 2006 ;
Location in patent: Page/Page column 22 ;
反应条件
1: 84 percent / KI, Bu4NCl, K2CO3 / acetone / 7 h / Heating
2: 1.) NaH / 1.) DMF, 10 min, 2.) 100 deg C
3: KOH / methanol / Heating
View Scheme
参考文献
Astles; Brown; Handscombe; Harper; Harris; Lewis; Lockey; McCarthy; McLay; Porter; Roach; Smith; Walsh
European Journal of Medicinal Chemistry, 1997 , vol. 32, # 5 p. 409 - 423
反应条件
tetrabutylammomium bromide; potassium carbonate; potassium iodide in acetone
Heating;
参考文献
Yuan, Lihua; Sanford, Adam R.; Feng, Wen; Zhang, Aimin; Zhu, Jin; Zeng, Huaqiang; Yamato, Kazuhiro; Li, Minfeng; Ferguson, Joseph S.; Gong, Bing
Journal of Organic Chemistry, 2005 , vol. 70, # 26 p. 10660 - 10669
反应条件
1: 79 percent / K2CO3 / acetone / 25 h / Heating
2: 82 percent / 10 percent NaOH / 2 h / Heating
View Scheme
参考文献
Iwamochi, Hirotoshi; Yoshizawa, Atsushi
Molecular Crystals and Liquid Crystals, 2009 , vol. 509, # 1 p. 223 - 232
反应条件
1: 85 percent / KHCO3 / acetone / 6 h / Heating
2: 91 percent / aq. LiOH / methanol / 2 h / Heating
View Scheme
参考文献
Pintre, Inmaculada C.; Gimeno, Nelida; Serrano, Jose Luis; Ros, M. Blanca; Alonso, Ibon; Folcia, Cesar L.; Ortega, Josu; Etxebarria, Jesus
Journal of Materials Chemistry, 2007 , vol. 17, # 21 p. 2219 - 2227
反应条件
potassium carbonate in acetone
5 h; Heating / reflux;
参考文献
WYETH
Patent: US2005/70584 A1, 2005 ;
Location in patent: Page/Page column 14 ;
反应条件
1: 48 percent / K2CO3 / butan-2-one / 72 h / Heating
2: 78 percent / 4 h / 190 °C
View Scheme
参考文献
Marshall; Goodson; Cullinan; Swanson-Bean; Haisch; Rinkema; Fleisch
Journal of Medicinal Chemistry, 1987 , vol. 30, # 4 p. 682 - 689
反应条件
potassium carbonate in acetone
Heating;
参考文献
Ishiguro, Masaji; Tatsuoka, Toshio; Nakatsuka, Nobuo
Tetrahedron Letters, 1982 , vol. 23, # 38 p. 3859 - 3862
参考文献
Merck Patent Gesellschaft mit beschrankter Haftung
Patent: US4616090 A1, 1986 ;
