(S)-2-氨基-5-(1,3-二氧戊环-2-基)戊酸合成路线 （共 4 条）
反应条件
sodium hydroxide in water T=65°C; pH=7.5; 5 h; Large scale reactionEnzymatic reaction;
参考文献
Cobley, Christopher J.; Lloyd, Michael C.; Simmonds, Shaun; Hanson, Christopher H.; Peng, Wei Jun
Organic Process Research and Development, 2011 , vol. 15, # 1 p. 284 - 290
反应条件
1: 98 percent / aq. NaOH; aq.NaHCO3 / dioxane 2: 97 percent / K2CO3 / dimethylformamide / 2 h / 20 °C 3: 98 percent / TsOH*H2ODMF / toluene / 2 h / 115 °C View Scheme
参考文献
Botman, Peter N. M.; Dommerholt, F. Jan; De Gelder, Rene; Broxterman, Quirinus B.; Schoemaker, Hans E.; Rutjes, Floris P. J. T.; Blaauw, Richard H.
Organic Letters, 2004 , vol. 6, # 26 p. 4941 - 4944
反应条件
1: 98 percent / aq. NaOH; aq.NaHCO3 / dioxane 2: 97 percent / K2CO3 / dimethylformamide / 2 h / 20 °C 3: 98 percent / TsOH*H2ODMF / toluene / 2 h / 115 °C 4: 90 percent / Oxone(R); NaHCO3 / 20 °C 5: H2 / Pd/C / methanol / 1.5 h 6: 57 mg / aq. HCl / 2.5 h / Heating View Scheme
参考文献
Botman, Peter N. M.; Dommerholt, F. Jan; De Gelder, Rene; Broxterman, Quirinus B.; Schoemaker, Hans E.; Rutjes, Floris P. J. T.; Blaauw, Richard H.
Organic Letters, 2004 , vol. 6, # 26 p. 4941 - 4944
反应条件
1: 98 percent / aq. NaOH; aq.NaHCO3 / dioxane
2: 97 percent / K2CO3 / dimethylformamide / 2 h / 20 °C
3: 98 percent / TsOH*H2ODMF / toluene / 2 h / 115 °C
4: 90 percent / Oxone(R); NaHCO3 / 20 °C
View Scheme
参考文献
Botman, Peter N. M.; Dommerholt, F. Jan; De Gelder, Rene; Broxterman, Quirinus B.; Schoemaker, Hans E.; Rutjes, Floris P. J. T.; Blaauw, Richard H.
Organic Letters, 2004 , vol. 6, # 26 p. 4941 - 4944
