2,3-二氢苯并呋喃-5-丙酸合成路线 （共 7 条）
反应条件
1: With sodium hydroxide; hydrogen; ammonium formate; palladium 10 on activated carbon in water T=20°C; 5 - 6 h; 2: With hydrogenchloride; water Product distribution / selectivity;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.
Patent: WO2008/151170 A2, 2008 ;
Location in patent: Page/Page column 5; 6; 14; 20; 36; 46; 63; 68 ;
反应条件
palladium 10 on activated carbon; hydrogen in acetic acid T=20°C; 1 h;
参考文献
Chen, Wen; Yang, Li-Juan; Li, Yan; Wang, Xue-Quan; Wang, Shao-Jie; Wan, Wei-Chao; Zhang, Hong-Bin; Yang, Xiao-Dong
Letters in Drug Design and Discovery, 2013 , vol. 10, # 7 p. 561 - 571
反应条件
1: 92 percent / TiCl4 / CH2Cl2 / 1 h 2: 62 percent / pyridine; piperidine / 4 h / 100 °C 3: 90 percent / H2; AcOH / 10percent Pd/C/H20 / 1 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 19 p. 4222 - 4239
反应条件
1: 62 percent / pyridine; piperidine / 4 h / 100 °C 2: 90 percent / H2; AcOH / 10percent Pd/C/H20 / 1 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 19 p. 4222 - 4239
反应条件
bromine; sodium acetate; acetic acid T=0 - 45°C; 2 - 3 h;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.
Patent: WO2008/151170 A2, 2008 ;
Location in patent: Page/Page column 5; 6; 14; 21; 36; 46; 63; 68 ;
反应条件
phosphoric acid T=80°C; 4 h;
参考文献
Wang, Bo; Zhang, Lijuan; Fu, Kaiyong; Luo, Yu; Lu, Wei; Tang, Jie
Organic Preparations and Procedures International, 2009 , vol. 41, # 4 p. 309 - 314
反应条件
1: SOCl2 / 0.67 h / 75 °C
2: 4.09 g / AlCl3 / 1,2-dichloro-ethane / 0.5 h / 20 °C
View Scheme
参考文献
Chen, Wen; Yang, Li-Juan; Li, Yan; Wang, Xue-Quan; Wang, Shao-Jie; Wan, Wei-Chao; Zhang, Hong-Bin; Yang, Xiao-Dong
Letters in Drug Design and Discovery, 2013 , vol. 10, # 7 p. 561 - 571
