6-(2-氨基乙基)-3-吡啶胺合成路线 （共 4 条）
反应条件
ammonium hydroxide; hydrogen in ethanol T=60°C; P=22502.3 Torr;
参考文献
ENSEMBLE THERAPEUTICS CORPORATION; ALEXANDER, Sethu L.; BRIGGS, Timothy F.; FAVALORO, Frank G., Jr.; HALE, Stephen P.; SEIGAL, Benjamin A.; SHORTSLEEVES, Kelley C.; SNEDEKER, Cheri; TAYLOR, Michael; TERRETT, Nicholas K.; YAN, Dingxue; NOWAK, Pawel, Wojciech; DENNY, Rajiah Aldrin; CHRUNYK, Boris Andrew; SAHASRABUDHE, Parag Vasant; WITHKA, Jane Marie
Patent: WO2014/66726 A2, 2014 ;
Location in patent: Paragraph 00193 ;
反应条件
1: potassium carbonate / tetrahydrofuran / 70 °C 2: toluene-4-sulfonic acid / toluene / 2 h / |Reflux 3: palladium 10 on activated carbon; hydrogen / tetrahydrofuran / 2 h / 20 °C / 7500.75 Torr 4: hydrogen; ammonium hydroxide / ethanol / 60 °C / 22502.3 Torr View Scheme
参考文献
ENSEMBLE THERAPEUTICS CORPORATION; ALEXANDER, Sethu L.; BRIGGS, Timothy F.; FAVALORO, Frank G., Jr.; HALE, Stephen P.; SEIGAL, Benjamin A.; SHORTSLEEVES, Kelley C.; SNEDEKER, Cheri; TAYLOR, Michael; TERRETT, Nicholas K.; YAN, Dingxue; NOWAK, Pawel, Wojciech; DENNY, Rajiah Aldrin; CHRUNYK, Boris Andrew; SAHASRABUDHE, Parag Vasant; WITHKA, Jane Marie
Patent: WO2014/66726 A2, 2014 ;
反应条件
1: toluene-4-sulfonic acid / toluene / 2 h / |Reflux 2: palladium 10 on activated carbon; hydrogen / tetrahydrofuran / 2 h / 20 °C / 7500.75 Torr 3: hydrogen; ammonium hydroxide / ethanol / 60 °C / 22502.3 Torr View Scheme
参考文献
ENSEMBLE THERAPEUTICS CORPORATION; ALEXANDER, Sethu L.; BRIGGS, Timothy F.; FAVALORO, Frank G., Jr.; HALE, Stephen P.; SEIGAL, Benjamin A.; SHORTSLEEVES, Kelley C.; SNEDEKER, Cheri; TAYLOR, Michael; TERRETT, Nicholas K.; YAN, Dingxue; NOWAK, Pawel, Wojciech; DENNY, Rajiah Aldrin; CHRUNYK, Boris Andrew; SAHASRABUDHE, Parag Vasant; WITHKA, Jane Marie
Patent: WO2014/66726 A2, 2014 ;
反应条件
1: palladium 10 on activated carbon; hydrogen / tetrahydrofuran / 2 h / 20 °C / 7500.75 Torr 2: hydrogen; ammonium hydroxide / ethanol / 60 °C / 22502.3 Torr View Scheme
参考文献
ENSEMBLE THERAPEUTICS CORPORATION; ALEXANDER, Sethu L.; BRIGGS, Timothy F.; FAVALORO, Frank G., Jr.; HALE, Stephen P.; SEIGAL, Benjamin A.; SHORTSLEEVES, Kelley C.; SNEDEKER, Cheri; TAYLOR, Michael; TERRETT, Nicholas K.; YAN, Dingxue; NOWAK, Pawel, Wojciech; DENNY, Rajiah Aldrin; CHRUNYK, Boris Andrew; SAHASRABUDHE, Parag Vasant; WITHKA, Jane Marie
Patent: WO2014/66726 A2, 2014 ;
