甲基2-(3,5-二氯-2,6-二羟基-4-甲基苯甲酰)-5-羟基-3-甲氧基苯甲酸酯合成路线 （共 18 条）
反应条件
1: 94 percent / aq. HCl / tetrahydrofuran / 2 h / 20 °C
2: 72 percent / K2CO3 / acetone / 1 h / 20 °C
3: 90 percent / Cs2CO3 / dimethylformamide / 1 h / 20 °C
4: 86 percent / n-BuLi / tetrahydrofuran; hexane / 3.25 h / -78 - 20 °C
5: 98 percent / Dess-Martin periodinane / CH2Cl2 / 0.75 h / 20 °C
6: 79 percent / H2 / Pd/C / ethanol / 1 h / 20 °C / 760 Torr
7: 95 percent / Dess-Martin periodinane / CH2Cl2 / 1 h / 20 °C
8: aq. NaH2PO4; NaClO2; 2-methyl-2-butene / tetrahydrofuran; 2-methyl-propan-2-ol / 1 h / 20 °C
9: 203 mg / diethyl ether; methanol / 0.17 h / 20 °C
10: 81 percent / p-TsOH / methanol / 4 h / Heating
View Scheme
参考文献
Katoh, Tadashi; Ohmori, Osamu; Iwasaki, Katsuhiko; Inoue, Munenori
Tetrahedron, 2002 , vol. 58, # 7 p. 1289 - 1299
反应条件
1: 79 percent / H2 / Pd/C / ethanol / 1 h / 20 °C / 760 Torr
2: 95 percent / Dess-Martin periodinane / CH2Cl2 / 1 h / 20 °C
3: aq. NaH2PO4; NaClO2; 2-methyl-2-butene / tetrahydrofuran; 2-methyl-propan-2-ol / 1 h / 20 °C
4: 203 mg / diethyl ether; methanol / 0.17 h / 20 °C
5: 81 percent / p-TsOH / methanol / 4 h / Heating
View Scheme
参考文献
Katoh, Tadashi; Ohmori, Osamu; Iwasaki, Katsuhiko; Inoue, Munenori
Tetrahedron, 2002 , vol. 58, # 7 p. 1289 - 1299
反应条件
1: 98 percent / Dess-Martin periodinane / CH2Cl2 / 0.75 h / 20 °C
2: 79 percent / H2 / Pd/C / ethanol / 1 h / 20 °C / 760 Torr
3: 95 percent / Dess-Martin periodinane / CH2Cl2 / 1 h / 20 °C
4: aq. NaH2PO4; NaClO2; 2-methyl-2-butene / tetrahydrofuran; 2-methyl-propan-2-ol / 1 h / 20 °C
5: 203 mg / diethyl ether; methanol / 0.17 h / 20 °C
6: 81 percent / p-TsOH / methanol / 4 h / Heating
View Scheme
参考文献
Katoh, Tadashi; Ohmori, Osamu; Iwasaki, Katsuhiko; Inoue, Munenori
Tetrahedron, 2002 , vol. 58, # 7 p. 1289 - 1299
反应条件
1: 59 percent / SO2Cl2 / CHCl3 / 1.5 h / 0 - 20 °C
2: 88 percent / Br2 / CH2Cl2; dimethylformamide / 3 h / 20 °C
3: 100 percent / DIPEA / CH2Cl2 / 1 h / 20 °C
4: 86 percent / n-BuLi / tetrahydrofuran; hexane / 3.25 h / -78 - 20 °C
5: 98 percent / Dess-Martin periodinane / CH2Cl2 / 0.75 h / 20 °C
6: 79 percent / H2 / Pd/C / ethanol / 1 h / 20 °C / 760 Torr
7: 95 percent / Dess-Martin periodinane / CH2Cl2 / 1 h / 20 °C
8: aq. NaH2PO4; NaClO2; 2-methyl-2-butene / tetrahydrofuran; 2-methyl-propan-2-ol / 1 h / 20 °C
9: 203 mg / diethyl ether; methanol / 0.17 h / 20 °C
10: 81 percent / p-TsOH / methanol / 4 h / Heating
View Scheme
参考文献
Katoh, Tadashi; Ohmori, Osamu; Iwasaki, Katsuhiko; Inoue, Munenori
Tetrahedron, 2002 , vol. 58, # 7 p. 1289 - 1299
反应条件
1: aq. NaH2PO4; NaClO2; 2-methyl-2-butene / tetrahydrofuran; 2-methyl-propan-2-ol / 1 h / 20 °C
2: 203 mg / diethyl ether; methanol / 0.17 h / 20 °C
3: 81 percent / p-TsOH / methanol / 4 h / Heating
View Scheme
参考文献
Katoh, Tadashi; Ohmori, Osamu; Iwasaki, Katsuhiko; Inoue, Munenori
Tetrahedron, 2002 , vol. 58, # 7 p. 1289 - 1299
反应条件
1: 95 percent / Dess-Martin periodinane / CH2Cl2 / 1 h / 20 °C
2: aq. NaH2PO4; NaClO2; 2-methyl-2-butene / tetrahydrofuran; 2-methyl-propan-2-ol / 1 h / 20 °C
3: 203 mg / diethyl ether; methanol / 0.17 h / 20 °C
4: 81 percent / p-TsOH / methanol / 4 h / Heating
View Scheme
参考文献
Katoh, Tadashi; Ohmori, Osamu; Iwasaki, Katsuhiko; Inoue, Munenori
Tetrahedron, 2002 , vol. 58, # 7 p. 1289 - 1299
反应条件
1: 203 mg / diethyl ether; methanol / 0.17 h / 20 °C
2: 81 percent / p-TsOH / methanol / 4 h / Heating
View Scheme
参考文献
Katoh, Tadashi; Ohmori, Osamu; Iwasaki, Katsuhiko; Inoue, Munenori
Tetrahedron, 2002 , vol. 58, # 7 p. 1289 - 1299
反应条件
dihydrogeodin oxidase; oxygen
T=30°C; pH=6.0;
参考文献
Fujii; Iijima; Ebizuka; Sankawa
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 1 p. 337 - 340
