3'-叠氮基-3'-脱氧-5-甲基尿苷合成路线 （共 3 条）
反应条件
1.1: pyridine / 7 h / 65 °C 1.2: 92.7 percent / pyridine / 48 h / 20 °C 2.1: 81 percent / trifluoromethanesulfonyl chloride; DMAP / CH2Cl2 / 2 h 3.1: 88.1 percent / NaOH / ethanol; H2O / 4 h / 20 °C View Scheme
参考文献
Van Rompaey, Philippe; Nauwelaerts, Koen; Vanheusden, Veerle; Rozenski, Jef; Munier-Lehmann, Helene; Herdewijn, Piet; Van Calenbergh, Serge
European Journal of Organic Chemistry, 2003 , # 15 p. 2911 - 2918
反应条件
1.1: pyridine / 7 h / 65 °C 1.2: 92.7 percent / pyridine / 48 h / 20 °C 2.1: 81 percent / trifluoromethanesulfonyl chloride; DMAP / CH2Cl2 / 2 h 3.1: 88.1 percent / NaOH / ethanol; H2O / 4 h / 20 °C 4.1: DAST; pyridine / toluene / 2 h / 20 °C 4.2: 90 percent / toluene / 5 h / 50 °C 5.1: 64 percent / HOAc / 0.42 h / 90 °C View Scheme
参考文献
Van Rompaey, Philippe; Nauwelaerts, Koen; Vanheusden, Veerle; Rozenski, Jef; Munier-Lehmann, Helene; Herdewijn, Piet; Van Calenbergh, Serge
European Journal of Organic Chemistry, 2003 , # 15 p. 2911 - 2918
反应条件
1.1: pyridine / 7 h / 65 °C 1.2: 92.7 percent / pyridine / 48 h / 20 °C 2.1: 81 percent / trifluoromethanesulfonyl chloride; DMAP / CH2Cl2 / 2 h 3.1: 88.1 percent / NaOH / ethanol; H2O / 4 h / 20 °C 4.1: DAST; pyridine / toluene / 2 h / 20 °C 4.2: 90 percent / toluene / 5 h / 50 °C View Scheme
参考文献
Van Rompaey, Philippe; Nauwelaerts, Koen; Vanheusden, Veerle; Rozenski, Jef; Munier-Lehmann, Helene; Herdewijn, Piet; Van Calenbergh, Serge
European Journal of Organic Chemistry, 2003 , # 15 p. 2911 - 2918
