1: 88 percent / K2CO3 / methanol / 0.5 h 2: 89 percent / K2CO3 / acetone / 1 h 3: 84 percent / LiAlH4 / diethyl ether; tetrahydrofuran / 1 h / 0 °C 4: 74 percent / H2 / PtO2/C / ethanol / 1 h View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1098214', constants.ctx, '0')">hydrogenchloride</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1098229', constants.ctx, '0')">methanol</a> <br />2&nbsp;h;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 5 mg / DIPEA / CH₂Cl₂ / 3 h / Ambient temperature<br />2: 85.5 percent / aq. HCl / methanol / 2 h<br /> <br /> &nbsp;