1-溴-2,4,6-三异丙苯合成路线 （共 33 条）
反应条件
1: 2-bromo-1,3,5-triisopropylbenzene With magnesium; ethylene dibromide in tetrahydrofuran T=65°C; Inert atmosphere; 2: 1-bromo-2-chloro-benzene in tetrahydrofuran T=65°C; 2 h; 3: dicyclohexylbromophosphine With copper(l) chloride in tetrahydrofuran T=20°C; 10 h; Inert atmosphere;
参考文献
Liu, Lei; Wu, Hai-Chen; Yu, Jin-Quan
Chemistry - A European Journal, 2011 , vol. 17, # 39 p. 10828 - 10831
反应条件
1: 2-bromo-1,3,5-triisopropylbenzene With magnesium; ethylene dibromide in tetrahydrofuran T=65°C; 1 h; 2: 1-bromo-2-chloro-benzene in tetrahydrofuran T=65°C; 1 h; 3: chlorodi-tert-butylphosphine With copper(l) chloride in tetrahydrofuran T=20°C; 20 h;
参考文献
Journal of the American Chemical Society, , vol. 125, # 22 p. 6653 - 6655
反应条件
tripotassium phosphate monohydrate; R-Phos; bis(dibenzylideneacetone)-palladium(0) in tetrahydrofuran T=20°C; Suzuki coupling; 18 h; Inert atmosphere;
参考文献
Hoshi, Takashi; Saitoh, Ippei; Nakazawa, Taichi; Suzuki, Toshio; Sakai, Jun-Ichi; Hagiwara, Hisahiro
Journal of Organic Chemistry, 2009 , vol. 74, # 10 p. 4013 - 4016
反应条件
1: 2-bromo-1,3,5-triisopropylbenzene With magnesium; ethylene dibromide in tetrahydrofuran T=60°C; 0.25 h; 2: 1,2-Dibromo-3,4,5,6-tetramethylbenzene in tetrahydrofuran T=60°C; 1.5 h; 3: chlorodi-tert-butylphosphine With copper(l) iodide in tetrahydrofuran T=75°C; 40 h;
参考文献
Journal of the American Chemical Society, , vol. 127, # 22 p. 8146 - 8149
反应条件
2,2'-azo-bisisobutyronitrile in benzene T=80°C; 3 h; Rate constantMechanism;
参考文献
Crich, David; Hwang, Jae-Taeg; Gastaldi, Stephane; Recupero, Francesco; Wink, Donald J.
Journal of Organic Chemistry, 1999 , vol. 64, # 8 p. 2877 - 2882
反应条件
1: 1.) t-BuLi / 1.) THF, pentane, -78 deg C, 30 min, 2.) 15 min 2: thionyl chloride / 16 h / Heating View Scheme
参考文献
Fuson; Horning
Journal of the American Chemical Society, 1940 , vol. 62, p. 2962
反应条件
1: 1.) t-BuLi / 1.) THF, pentane, -78 deg C, 30 min, 2.) 15 min 2: 89 percent / tetra-n-butylammonium hydrogen sulfate, NaOH / CHCl3; H2O / 16 h / Ambient temperature View Scheme
参考文献
Beak, Peter; Carter, Linda G.
Journal of Organic Chemistry, 1981 , vol. 46, # 11 p. 2363 - 2373
反应条件
tert.-butyl lithium 1.) THF, hexane, -78 deg C, 30 min, 2.) 30 min; Yield given. Multistep reaction;
参考文献
Beak, Peter; Carter, Linda G.
Journal of Organic Chemistry, 1981 , vol. 46, # 11 p. 2363 - 2373
反应条件
triethylamine; bis(dibenzylideneacetone)-palladium(0) in 1,4-dioxane T=100°C; 6 h;
参考文献
Murata, Miki; Sambommatsu, Tomoko; Watanabe, Shinji; Masuda, Yuzuru
Synlett, 2006 , # 12 p. 1867 - 1870
反应条件
1: 2-bromo-1,3,5-triisopropylbenzene With 1,2-dibrom-methane; magnesium in tetrahydrofuran 3.5 h; Heating; 2: 2,4,6-tribromo-1-iodobenzene in tetrahydrofuran 5 h; Heating; Further stages.;
参考文献
Journal of the American Chemical Society, , vol. 124, # 22 p. 6252 - 6253
