6-(4-甲氧基-苯基)-1,3-二氢-吲哚-2-酮合成路线 （共 5 条）
反应条件
hydrogenchloride; tin in ethanol; water 3 h; Heating / reflux;
参考文献
DCB-USA LLC
Patent: WO2009/85040 A1, 2009 ;
Location in patent: Page/Page column 26 ;
反应条件
iron; acetic acid T=100°C; reductive cyclization;
参考文献
Sun, Li; Tran, Ngoc; Liang, Congxin; Tang, Flora; Rice, Audie; Schreck, Randall; Waltz, Kara; Shawver, Laura K.; McMahon, Gerald; Tang, Cho
Journal of Medicinal Chemistry, 1999 , vol. 42, # 25 p. 5120 - 5130
反应条件
in acetic acid; ethyl acetate
参考文献
Sugen, Inc.
Patent: US6114371 A1, 2000 ;
US 6114371 A
反应条件
1.1: (Ph3P)4Pd; NaHCO3 / toluene / 2 h / Heating 2.1: NaH; DMSO / 0.17 h / 100 °C 2.2: dimethylsulfoxide / 2 h / 100 °C 3.1: 6 N aq. HCl / 15 h / 100 °C 4.1: 38 percent / Fe; AcOH / 100 °C View Scheme
参考文献
Sun, Li; Tran, Ngoc; Liang, Congxin; Tang, Flora; Rice, Audie; Schreck, Randall; Waltz, Kara; Shawver, Laura K.; McMahon, Gerald; Tang, Cho
Journal of Medicinal Chemistry, 1999 , vol. 42, # 25 p. 5120 - 5130
反应条件
1.1: NaH; DMSO / 0.17 h / 100 °C 1.2: dimethylsulfoxide / 2 h / 100 °C 2.1: 6 N aq. HCl / 15 h / 100 °C 3.1: 38 percent / Fe; AcOH / 100 °C View Scheme
参考文献
Sun, Li; Tran, Ngoc; Liang, Congxin; Tang, Flora; Rice, Audie; Schreck, Randall; Waltz, Kara; Shawver, Laura K.; McMahon, Gerald; Tang, Cho
Journal of Medicinal Chemistry, 1999 , vol. 42, # 25 p. 5120 - 5130
