6-(3-乙氧基-苯基)-1,3-二氢-吲哚-2-酮合成路线 （共 5 条）
参考文献
Sugen, Inc.
Patent: US6051593 A1, 2000 ;
反应条件
iron; acetic acid in methanol
reductive cyclization; 2 h; Heating;
参考文献
Sugen, Inc.
Patent: US6350754 B2, 2002 ;
Location in patent: Page column 29 ;
反应条件
1.1: (Ph3P)4Pd; NaHCO3 / toluene / 2 h / Heating
2.1: NaH; DMSO / 0.17 h / 100 °C
2.2: dimethylsulfoxide / 2 h / 100 °C
3.1: 6 N aq. HCl / 96 h / 100 °C
4.1: 91 percent / Fe; AcOH / methanol / 2 h / Heating
View Scheme
参考文献
Sun, Li; Tran, Ngoc; Liang, Congxin; Tang, Flora; Rice, Audie; Schreck, Randall; Waltz, Kara; Shawver, Laura K.; McMahon, Gerald; Tang, Cho
Journal of Medicinal Chemistry, 1999 , vol. 42, # 25 p. 5120 - 5130
反应条件
1.1: NaH; DMSO / 0.17 h / 100 °C
1.2: dimethylsulfoxide / 2 h / 100 °C
2.1: 6 N aq. HCl / 96 h / 100 °C
3.1: 91 percent / Fe; AcOH / methanol / 2 h / Heating
View Scheme
参考文献
Sun, Li; Tran, Ngoc; Liang, Congxin; Tang, Flora; Rice, Audie; Schreck, Randall; Waltz, Kara; Shawver, Laura K.; McMahon, Gerald; Tang, Cho
Journal of Medicinal Chemistry, 1999 , vol. 42, # 25 p. 5120 - 5130
反应条件
1: 6 N aq. HCl / 96 h / 100 °C
2: 91 percent / Fe; AcOH / methanol / 2 h / Heating
View Scheme
参考文献
Sun, Li; Tran, Ngoc; Liang, Congxin; Tang, Flora; Rice, Audie; Schreck, Randall; Waltz, Kara; Shawver, Laura K.; McMahon, Gerald; Tang, Cho
Journal of Medicinal Chemistry, 1999 , vol. 42, # 25 p. 5120 - 5130
