4,6-二甲氧基-2,3-二氧代吲哚啉合成路线 （共 9 条）
参考文献
Zhang, Ai Hua; Jiang, Nan; Gu, Wen; Ma, Jing; Wang, Yu Rong; Song, Yong Chun; Tan, Ren Xiang
Chemistry - A European Journal, 2010 , vol. 16, # 48 p. 14479 - 14485
反应条件
1: hydrogenchloride / diethyl ether / 1.5 h / 0 - 10 °C 2: diethyl ether / 2 h / 170 °C View Scheme
反应条件
lithium aluminium tetrahydride in 1,4-dioxane 12 h; Reflux;
参考文献
Jumina; Kumar, Naresh; Black, David St.C.
Tetrahedron, 2009 , vol. 65, # 12 p. 2591 - 2598
反应条件
1.1: sodium hydroxide; dihydrogen peroxide / tetrahydrofuran; water / 70 °C 1.2: 3 h / 20 °C 1.3: 16 h / 20 °C 2.1: N,N-dimethyl-formamide / 1 h / 70 °C 2.2: 16 h / 70 °C View Scheme
反应条件
dihydrogen peroxide; sodium hydroxide in water T=100°C;
参考文献
Zhang, Ai Hua; Jiang, Nan; Gu, Wen; Ma, Jing; Wang, Yu Rong; Song, Yong Chun; Tan, Ren Xiang
Chemistry - A European Journal, 2010 , vol. 16, # 48 p. 14479 - 14485
反应条件
1.1: NaOH / methanol / 1 h / Heating
1.2: 3.9 g / dimethylformamide / 16 h / 100 °C
2.1: 76 percent / aq. NaOH / 12 h / Heating
View Scheme
参考文献
Jones, Ashley W.; Purwono, Bambang; Bowyer, Paul K.; Mitchell, Peter S.R.; Kumar, Naresh; Nugent, Stephen J.; Jolliffe, Katrina A.; Black, David StC.
Tetrahedron, 2004 , vol. 60, # 47 p. 10779 - 10786
反应条件
1: 50 percent / NaOH; aq. H2O2 / 0.17 h / 100 °C
2: tetrahydrofuran; methanol / 20 °C
View Scheme
参考文献
Guengoer, Timur; Chen, Ying; Golla, Rajasree; Ma, Zhengping; Corte, James R.; Northrop, John P.; Bin, Bin; Dickson, John K.; Stouch, Terry; Zhou, Rong; Johnson, Susan E.; Seethala, Ramakrishna; Feyen, Jean H. M.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 8 p. 2440 - 2455
反应条件
1: With dihydrogen peroxide; sodium hydroxide in tetrahydrofuran; water
T=70°C;
2: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in tetrahydrofuran
T=20°C; 3 h;
3: With ammonia in tetrahydrofuran; water
T=20°C; 16 h;
参考文献
RVX Therapeutics Inc.; McLure, Kevin G.; Young, Peter Ronald
Patent: US2013/281397 A1, 2013 ;
Location in patent: Paragraph 0452; 0453; 0454 ;
反应条件
1: 50 percent / NaOH; aq. H2O2 / 0.17 h / 100 °C
2: 92 percent / tetrahydrofuran / 0 - 20 °C
View Scheme
参考文献
Guengoer, Timur; Chen, Ying; Golla, Rajasree; Ma, Zhengping; Corte, James R.; Northrop, John P.; Bin, Bin; Dickson, John K.; Stouch, Terry; Zhou, Rong; Johnson, Susan E.; Seethala, Ramakrishna; Feyen, Jean H. M.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 8 p. 2440 - 2455
