N-[7-(羟基甲基)-1-异喹啉基]苯甲酰胺合成路线 （共 6 条）
反应条件
1: pyridine / 1 h / 125 °C
2: n-BuLi / tetrahydrofuran / 0.5 h / -78 °C
3: NaBH4 / tetrahydrofuran; methanol / 0.08 h / 20 °C
View Scheme
参考文献
Rewinkel; Lucas; Smit; Noach; Van Dinther; Rood; Jenneboer; Van Boeckel
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 19 p. 2837 - 2842
反应条件
1: KOH; PhOH / 2 h / 140 °C
2: NH4OAc / 14 h / 150 °C
3: pyridine / 1 h / 125 °C
4: n-BuLi / tetrahydrofuran / 0.5 h / -78 °C
5: NaBH4 / tetrahydrofuran; methanol / 0.08 h / 20 °C
View Scheme
参考文献
Rewinkel; Lucas; Smit; Noach; Van Dinther; Rood; Jenneboer; Van Boeckel
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 19 p. 2837 - 2842
反应条件
1: pyridine / 1 h / 125 °C
2: n-BuLi / tetrahydrofuran / 0.5 h / -78 °C
3: NaBH4 / tetrahydrofuran; methanol / 0.08 h / 20 °C
View Scheme
参考文献
Rewinkel; Lucas; Smit; Noach; Van Dinther; Rood; Jenneboer; Van Boeckel
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 19 p. 2837 - 2842
反应条件
1: NH4OAc / 14 h / 150 °C
2: pyridine / 1 h / 125 °C
3: n-BuLi / tetrahydrofuran / 0.5 h / -78 °C
4: NaBH4 / tetrahydrofuran; methanol / 0.08 h / 20 °C
View Scheme
参考文献
Rewinkel; Lucas; Smit; Noach; Van Dinther; Rood; Jenneboer; Van Boeckel
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 19 p. 2837 - 2842
反应条件
1: n-BuLi / tetrahydrofuran / 0.5 h / -78 °C
2: NaBH4 / tetrahydrofuran; methanol / 0.08 h / 20 °C
View Scheme
参考文献
Rewinkel; Lucas; Smit; Noach; Van Dinther; Rood; Jenneboer; Van Boeckel
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 19 p. 2837 - 2842
反应条件
1: Et3N / CH2Cl2 / 2 h / 20 °C
2: LiCl / tetrahydrofuran / 16 h / 20 °C
View Scheme
参考文献
Rewinkel; Lucas; Smit; Noach; Van Dinther; Rood; Jenneboer; Van Boeckel
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 19 p. 2837 - 2842
