1: cyclopropanecarboxylic acid With 1,1'-carbonyldiimidazole in N,N-dimethyl-formamide T=0°C; 1.5 h; 2: magnesium acetoacetate in N,N-dimethyl-formamide T=0 - 20°C; 92 h; 3: With hydrogenchloride; water in N,N-dimethyl-formamide
1: With chloro-trimethyl-silane in dichloromethane
T=0 - 5°C; 0.5 h; Inert atmosphereLarge scale reaction;
2: With N-chloro-succinimide in dichloromethane
T=0 - 5°C; 2.08333 h; Inert atmosphereLarge scale reaction;
参考文献
Bradley, Paul A.; De Koning, Pieter D.; Johnson, Patrick S.; Lecouturier, Yann C.; McManus, David J.; Robin, Aurelie; Underwood, Toby J.
Organic Process Research and Development, 2009 , vol. 13, # 5 p. 848 - 853
