3-(3-溴苯基)-3-氧-丙酸乙酯合成路线 （共 9 条）
反应条件
1: 1-(3-bromophenyl)ethanone With sodium hydride in DMF (N,N-dimethyl-formamide) T=0 - 20°C; 0.583333 h; 2: oxalic acid diethyl ester in DMF (N,N-dimethyl-formamide) T=0 - 20°C; 16 h; 3: With hydrogenchloride; water in DMF (N,N-dimethyl-formamide)
参考文献
MERCK and CO., INC.
Patent: WO2004/92140 A1, 2004 ;
Location in patent: Page 56-57 ;
WO 2004/092140 A1
反应条件
Magnesium chloride; triethylamine in acetonitrile
参考文献
Iwanowicz, Edwin J.; Watterson, Scott H.; Dhar, T.G. Murali; Pitts, William J.; Gu, Henry H.
Patent: US2002/40022 A1, 2002 ;
反应条件
manganese(IV) oxide in dichloromethane T=20°C;
参考文献
Kafle, Bhooshan; Aher, Nilkanth G.; Khadka, Deegendra; Park, Hwangseo; Cho, Hyeongjin
Chemistry - An Asian Journal, 2011 , vol. 6, # 8 p. 2073 - 2079
反应条件
sodium hydride in benzene Heating;
参考文献
Gasparotto, Venusia; Castagliuolo, Ignazio; Chiarelotto, Gianfranco; Pezzi, Vincenzo; Montanaro, Daniela; Brun, Paola; Palu, Giorgio; Viola, Giampietro; Ferlin, Maria Grazia
Journal of Medicinal Chemistry, 2006 , vol. 49, # 6 p. 1910 - 1915
反应条件
niobium pentachloride in dichloromethane T=27°C; 4.5 h;
参考文献
Yadav; Subba Reddy; Eeshwaraiah; Reddy
Tetrahedron, 2005 , vol. 61, # 4 p. 875 - 878
反应条件
copper(II) sulfate T=20°C; 39 h;
参考文献
Liao, Mingyi; Wang, Jianbo
Tetrahedron Letters, 2006 , vol. 47, # 50 p. 8859 - 8861
反应条件
1.1: 85 percent / DBU / H2O / 24 h / 20 °C 2.1: triethylamine / CH2Cl2 / 0.08 h / 0 °C 2.2: CH2Cl2 / 2 h / 0 - 20 °C 3.1: Rh2(OAc)4 / CH2Cl2 / 20 °C 3.2: 28 percent / silica gel View Scheme
参考文献
Tetrahedron Letters, , vol. 48, # 7 p. 1147 - 1149
反应条件
sodium hydride in various solvent(s) Heating;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 11, # 13 p. 2991 - 3013
反应条件
sodium ethanolate
18 h; Ambient temperature;
参考文献
Cocco; Maccioni; Plumitallo
Farmaco, Edizione Scientifica, 1985 , vol. 40, # 4 p. 272 - 284
