2-氨基-4,6-二甲氧基苯甲酸合成路线 （共 14 条）
反应条件
dihydrogen peroxide; sodium hydroxide in water T=100°C;
参考文献
Zhang, Ai Hua; Jiang, Nan; Gu, Wen; Ma, Jing; Wang, Yu Rong; Song, Yong Chun; Tan, Ren Xiang
Chemistry - A European Journal, 2010 , vol. 16, # 48 p. 14479 - 14485
反应条件
hydrogen; palladium 10 on activated carbon in methanol; N,N-dimethyl-formamide T=20°C; P=262.526 Torr; 24 h;
参考文献
WO2007/65662 A2, ;
Page/Page column 59-60 ;
WO 2007/065662 A2
反应条件
1: 100 percent / 0.5 h / 165 °C 2: 50 percent / NaOH; aq. H2O2 / 0.17 h / 100 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 8 p. 2440 - 2455
反应条件
in tetrahydrofuran; water
参考文献
Gungor, Timur; Corte, James R.
Patent: US2003/220227 A1, 2003 ;
US 20030220227 A1
反应条件
1: 95 percent / ethanol; CH2Cl2 / 0 °C
2: 94 percent / 2-methoxy-ethanol / 2 h / Heating
3: POCl3; DIPEA / 1,2-dichloro-ethane / 2 h / Heating
View Scheme
参考文献
Hennequin, Laurent F.; Allen, Jack; Breed, Jason; Curwen, Jon; Fennell, Michael; Green, Tim P.; Lambert-Van Der Brempt, Christine; Morgentin, Remy; Norman, Richard A.; Olivier, Annie; Otterbein, Ludovic; Ple, Patrick A.; Warin, Nicolas; Costello, Gerard
Journal of Medicinal Chemistry, 2006 , vol. 49, # 22 p. 6465 - 6488
反应条件
1: 95 percent / ethanol; CH2Cl2 / 0 °C
2: 94 percent / 2-methoxy-ethanol / 2 h / Heating
3: 98 percent / MgBr2; pyridine / 1.5 h / Heating
View Scheme
参考文献
Hennequin, Laurent F.; Allen, Jack; Breed, Jason; Curwen, Jon; Fennell, Michael; Green, Tim P.; Lambert-Van Der Brempt, Christine; Morgentin, Remy; Norman, Richard A.; Olivier, Annie; Otterbein, Ludovic; Ple, Patrick A.; Warin, Nicolas; Costello, Gerard
Journal of Medicinal Chemistry, 2006 , vol. 49, # 22 p. 6465 - 6488
反应条件
1.1: 95 percent / ethanol; CH2Cl2 / 0 °C
2.1: 94 percent / 2-methoxy-ethanol / 2 h / Heating
3.1: 98 percent / MgBr2; pyridine / 1.5 h / Heating
4.1: NaH / dimethylformamide / 1 h / 20 °C
4.2: 83 percent / dimethylformamide / 1 h / 0 °C
5.1: 88 percent / PPh3; DTAD / CH2Cl2 / 1 h / 20 °C
6.1: 100 percent / K2CO3; PhSH / 1-methyl-pyrrolidin-2-one / 0.58 h / 195 °C
7.1: 57 percent / pyridine / 2 h / 120 °C
8.1: 66 percent / PPh3; CCl4 / 1,2-dichloro-ethane / 2 h / 70 °C
9.1: 78 percent / NH3 / methanol / 2 h / 20 °C
View Scheme
参考文献
Hennequin, Laurent F.; Allen, Jack; Breed, Jason; Curwen, Jon; Fennell, Michael; Green, Tim P.; Lambert-Van Der Brempt, Christine; Morgentin, Remy; Norman, Richard A.; Olivier, Annie; Otterbein, Ludovic; Ple, Patrick A.; Warin, Nicolas; Costello, Gerard
Journal of Medicinal Chemistry, 2006 , vol. 49, # 22 p. 6465 - 6488
反应条件
in ethanol; dichloromethane
T=0°C;
参考文献
Hennequin, Laurent F.; Allen, Jack; Breed, Jason; Curwen, Jon; Fennell, Michael; Green, Tim P.; Lambert-Van Der Brempt, Christine; Morgentin, Remy; Norman, Richard A.; Olivier, Annie; Otterbein, Ludovic; Ple, Patrick A.; Warin, Nicolas; Costello, Gerard
Journal of Medicinal Chemistry, 2006 , vol. 49, # 22 p. 6465 - 6488
反应条件
sodium hydroxide in ethanol; dichloromethane
参考文献
AstraZeneca AB
Patent: EP1292594 B1, 2004 ;
反应条件
in tetrahydrofuran; methanol
T=20°C;
参考文献
Gungor, Timur; Corte, James R.
Patent: US2003/220227 A1, 2003 ;
US 20030220227 A1
