2-氨基-4,6-二甲氧基苯甲酸合成路线 （共 14 条）
反应条件
1: 95 percent / ethanol; CH2Cl2 / 0 °C
2: 94 percent / 2-methoxy-ethanol / 2 h / Heating
View Scheme
参考文献
Hennequin, Laurent F.; Allen, Jack; Breed, Jason; Curwen, Jon; Fennell, Michael; Green, Tim P.; Lambert-Van Der Brempt, Christine; Morgentin, Remy; Norman, Richard A.; Olivier, Annie; Otterbein, Ludovic; Ple, Patrick A.; Warin, Nicolas; Costello, Gerard
Journal of Medicinal Chemistry, 2006 , vol. 49, # 22 p. 6465 - 6488
反应条件
1: With 4-methyl-morpholine; benzotriazol-1-ol; N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide in tetrahydrofuran
T=20°C; 3 h;
2: With ammonia in tetrahydrofuran; water
T=20°C; 16 h;
参考文献
Resverlogix Corp.
Patent: WO2008/92231 A1, 2008 ;
Location in patent: Page/Page column 56-58 ;
WO 2008/092231 A1
反应条件
in tetrahydrofuran
T=0 - 20°C;
参考文献
Guengoer, Timur; Chen, Ying; Golla, Rajasree; Ma, Zhengping; Corte, James R.; Northrop, John P.; Bin, Bin; Dickson, John K.; Stouch, Terry; Zhou, Rong; Johnson, Susan E.; Seethala, Ramakrishna; Feyen, Jean H. M.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 8 p. 2440 - 2455
参考文献
American Home Products Corporation
Patent: US3966965 A1, 1976 ;
Title/Abstract Full Text Show Details
American Home Products Corporation
Patent: US4160100 A1, 1979 ;
Title/Abstract Full Text Show Details
American Home Products Corporation
Patent: US4054661 A1, 1977 ;
