6-溴-1,2,3,4-四氢异喹啉盐酸盐合成路线 （共 4 条）
反应条件
1: With tri-ruthenium(0)dodecacarbonyl; (HSiMe2)2NH in toluene T=20 - 50°C; 24.17 h; Inert atmosphere; 2: With hydrogenchloride in 1,4-dioxane; ethyl acetate; toluene T=20°C; 0.5 h;
参考文献
Reeves, Jonathan T.; Tan, Zhulin; Marsini, Maurice A.; Han, Zhengxu S.; Xu, Yibo; Reeves, Diana C.; Lee, Heewon; Lu, Bruce Z.; Senanayake, Chris H.
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 1 p. 47 - 52
反应条件
1: With 1-chloroethyl chlorocarbonate Reflux; 2: With methanol 4 h; Reflux;
参考文献
Synthetic Communications, , vol. 39, # 17 p. 3060 - 3068
反应条件
1.1: triethylamine / methanol / 20 °C / Inert atmosphere 2.1: 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 0.08 h / 20 °C / Inert atmosphere 2.2: 4 h / 90 °C / Inert atmosphere View Scheme
参考文献
WO2010/146105 A1, ;
WO 2010/146105 A1
反应条件
triethylamine in methanol T=20°C; 20 h; Inert atmosphere;
参考文献
WO2010/145202 A1, ;
Page/Page column 35-36 ;
WO 2010/145202 A1
