2-(4-溴-2-甲基苯基)乙腈合成路线 （共 8 条）
反应条件
in water; N,N-dimethyl-formamide T=0 - 20°C;
参考文献
ASTRAZENECA AB
Patent: WO2008/18827 A1, 2008 ;
Location in patent: Page/Page column 61-62 ;
WO 2008/018827 A1
反应条件
in N,N-dimethyl-formamide T=20 - 25°C; Inert atmosphere;
参考文献
PFIZER INC.; BROWN, Matthew Frank; MARFAT, Anthony; MELNICK, Michael Joseph; REILLY, Usa
Patent: WO2011/45703 A2, 2011 ;
Location in patent: Page/Page column 40 ;
WO 2011/045703 A2
反应条件
in tetrahydrofuran T=0 - 20°C; 6 h;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2008/55847 A1, 2008 ;
Location in patent: Page/Page column 54-55 ;
WO 2008/055847 A1
反应条件
tetrabutylammomium bromide in dichloromethane; water T=0 - 20°C; 16 h;
参考文献
AFRAXIS, INC.; CAMPBELL, David; DURÓN, Sergio, G.
Patent: WO2013/43232 A2, 2013 ;
Location in patent: Paragraph 00620 ;
WO 2013/043232 A2
反应条件
in water; N,N-dimethyl-formamide T=80°C; 72 h;
参考文献
SANKYO COMPANY, LIMITED
Patent: WO2006/109633 A1, 2006 ;
Location in patent: Page/Page column 168-169 ;
反应条件
1: diborane / tetrahydrofuran / 1.5 h / 0 - 25 °C 2: thionyl chloride / 1.5 h / Reflux 3: N,N-dimethyl-formamide / 20 - 25 °C / Inert atmosphere View Scheme
参考文献
AFRAXIS, INC.; CAMPBELL, David; DURÓN, Sergio, G.
Patent: WO2013/43232 A2, 2013 ;
WO 2013/043232 A2
反应条件
1: thionyl chloride / 1.5 h / Reflux 2: N,N-dimethyl-formamide / 20 - 25 °C / Inert atmosphere View Scheme
参考文献
AFRAXIS, INC.; CAMPBELL, David; DURÓN, Sergio, G.
Patent: WO2013/43232 A2, 2013 ;
WO 2013/043232 A2
反应条件
1: lithium aluminium tetrahydride / dichloromethane / 16 h / 0 - 20 °C 2: phosphorus tribromide / dichloromethane / 3 h / 0 - 20 °C 3: tetrabutylammomium bromide / dichloromethane; water / 16 h / 0 - 20 °C View Scheme
参考文献
AFRAXIS, INC.; CAMPBELL, David; DURÓN, Sergio, G.
Patent: WO2013/43232 A2, 2013 ;
WO 2013/043232 A2
