2-(4-溴-3-甲基苯基)乙腈合成路线 (共 2 条)
反应条件
tetrabutylammomium bromide in dichloromethane; water 6 h;
参考文献
ASTRAZENECA AB
Patent: WO2008/18827 A1, 2008 ;
Location in patent: Page/Page column 57; 58-59 ;
WO 2008/018827 A1
反应条件
1: 2-(4-bromo-3-methylphenyl)acetonitrile With hydrogenchloride; water in acetic acid
3 h; Heating / reflux;
2: methanol With sulfuric acid
T=20°C;
参考文献
SANKYO COMPANY, LIMITED
Patent: WO2006/46593 A1, 2006 ;
Location in patent: Page/Page column 265 ;