5-(2-甲氧基-2-氧代乙基)-2-甲基噁唑-4-羧酸甲酯合成路线 （共 3 条）
反应条件
1: With thionyl chloride in chloroform T=0°C; Reflux; 2: With sodium hydrogencarbonate in dichloromethane; water T=0°C;
参考文献
CHEMIZON, A DIVISION OF OPTOMAGIC CO., LTD.
Patent: US2012/238599 A1, 2012 ;
Location in patent: Page/Page column 30 ;
US 20120238599 A1
反应条件
1: 1.) Zinc dust, acetic acid, 2.) H2O / 1.) below 40 deg C, 10 min, 2.) room temperature, 2 h 2: SOCl2 / CHCl3 / Heating View Scheme
参考文献
CHEMIZON, A DIVISION OF OPTOMAGIC CO., LTD.
Patent: US2012/238599 A1, 2012 ;
US 20120238599 A1
反应条件
1.1: sodium nitrite; acetic acid / water / 0 - 20 °C 2.1: hydrogen / palladium 10 on activated carbon / 3 h / 20 °C 3.1: thionyl chloride / chloroform / 0 °C / Reflux 3.2: 0 °C View Scheme
参考文献
CHEMIZON, A DIVISION OF OPTOMAGIC CO., LTD.
Patent: US2012/238599 A1, 2012 ;
US 20120238599 A1
