6-溴-3H-恶唑并[4,5-b]吡啶-2-酮合成路线 （共 9 条）
反应条件
bromine in N,N-dimethyl-formamide T=20°C; 1.5 h;
参考文献
METHYLGENE INC.
Patent: WO2009/100536 A1, 2009 ;
Location in patent: Page/Page column 95-96 ;
WO 2009/100536 A1
反应条件
hydrogen; platinum(IV) oxide in ethanol
参考文献
Benarab; Boye; Savelon; Guillaumet
Tetrahedron Letters, 1993 , vol. 34, # 47 p. 7567 - 7568
反应条件
1.1: potassium hydroxide / ethanol; H2O 1.2: potassium permanganate; acetic acid 2.1: bromine / dimethylformamide View Scheme
参考文献
Phytochemistry, , vol. 66, # 15 p. 1797 - 1803
反应条件
in benzene 3 h; Heating;
参考文献
Hisano, Takuzo; Harano, Kazunobu; Fukuoka, Ryuichi; Matsuoka, Toshikazu; Muraoka, Keiji; Shinohara, Ikuo
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 4 p. 1485 - 1492
反应条件
sodium hydroxide; water Heating / reflux;
参考文献
PFIZER INC.
Patent: WO2006/21886 A1, 2006 ;
Location in patent: Page/Page column 64; 65 ;
WO 2006/021886 A1
反应条件
1: 92 percent / 10percent NaOH / H2O / 8 h / Heating 2: 1.) P2O5, hexamethyldisiloxane / 1.) 1,2-dichloroethane, reflux, 2 h, 2.) 200 deg C, 3 h View Scheme
参考文献
Viaud, Marie-Claude; Jamoneau, Patricia; Savelon, Laurence; Guillaumet, Gerald
Heterocycles, 1995 , vol. 41, # 12 p. 2799 - 2810
反应条件
ethanol; sodium 1.) room temperature 1 h, 2.) DMF, reflux, 2 h.; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Viaud, Marie-Claude; Jamoneau, Patricia; Baudin, Marie-Laure; Savelon, Laurence; Guillaumet, Gerald
Tetrahedron, 1997 , vol. 53, # 14 p. 5159 - 5168
参考文献
Rorer Pharmaceutical Corporation
Patent: US4866074 A1, 1989 ;
反应条件
sodium ethanolate in N,N-dimethyl-formamide T=130°C; 2 h; different halogeno derivatives or olefins and reaction conditions; Product distribution;
参考文献
Viaud, Marie-Claude; Jamoneau, Patricia; Savelon, Laurence; Guillaumet, Gerald
Tetrahedron Letters, 1996 , vol. 37, # 14 p. 2409 - 2412
