反应条件
1.1: CH2Cl2 / 16 h
2.1: N,N,N',N'-tetramethylethylenediamine; sec-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C
2.2: tetrahydrofuran; hexane / 1 h
3.1: aq. HCl / 12 h / 100 °C
View Scheme
参考文献
Wacker, Dean A.; Varnes, Jeffrey G.; Malmstrom, Sarah E.; Cao, Xueying; Hung, Chen-Pin; Ung, Thao; Wu, Ginger; Zhang, Ge; Zuvich, Eva; Thomas, Michael A.; Keim, William J.; Cullen, Mary Jane; Rohrbach, Kenneth W.; Qu, Qinling; Narayanan, Rangaraj; Rossi, Karen; Janovitz, Evan; Lehman-McKeeman, Lois; Malley, Mary F.; Devenny, James; Pelleymounter, Mary Ann; Miller, Keith J.; Robl, Jeffrey A.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 6 p. 1365 - 1379
