1: With triethylamine in anhydrous dichloroethane
T=20°C; 16 h;
2: With sulfuric acid; acetic anhydride in anhydrous dichloroethane
T=55°C; 5 h; Product distribution / selectivity;
1: CH2Cl2 / 2 h / 20 °C
2: thionyl chloride / 1 h / 25 °C
3: tetrahydrofuran / 2 h / 20 °C
View Scheme
参考文献
Carini, David J.; Duncia, John V.; Aldrich, Paul E.; Chiu, Andrew T.; Johnson, Alexander L.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2525 - 2547
Portnov, Yu. N.; Zabrodnyaya, V. G.; Voronin, V. G.; Kost, A. N.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983 , vol. 19, # 11 p. 1175 - 1179
Khimiya Geterotsiklicheskikh Soedinenii, 1983 , # 11 p. 1485 - 1489