7-氯-2,3-二氢喹啉-4-酮合成路线 （共 15 条）
参考文献
Rhone-Poulenc Sante
Patent: US4412076 A1, 1983 ;
反应条件
palladium on activated charcoal; water; cis-maleic acid
参考文献
Rhone-Poulenc Sante
Patent: US4412076 A1, 1983 ;
反应条件
hydrogenchloride in isopropyl alcohol 17 h; Heating;
参考文献
Werbel, L. M.; Kesten, S. J.; Turner, W. R.
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 11 p. 837 - 852
反应条件
sodium hydroxide; sodium chloride; sulfur trioxide
参考文献
Rhone-Poulenc Sante
Patent: US4421918 A1, 1983 ;
反应条件
trifluorormethanesulfonic acid in dichloromethane
T=0 - 18°C; Fries rearrangement; 1 h; Inert atmosphere;
参考文献
Lange, Jens; Bissember, Alex C.; Banwell, Martin G.; Cade, Ian A.
Australian Journal of Chemistry, 2011 , vol. 64, # 4 p. 454 - 470
反应条件
hydrogenchloride; water in acetic acid
5 h; Heating;
参考文献
McHugh, Michael; Proctor, George R.
Journal of Chemical Research, Miniprint, 1984 , # 8 p. 2230 - 2253
反应条件
1: 1.) PCl5, 2.) AlCl3 / 1.) benzene, from 5 deg C to 23 deg C, 30 min, 2.) benzene 15-20 deg C, 3.5 h
2: 74 percent / gl. AcOH, aq. HCl / 3.5 h / Heating
View Scheme
参考文献
Werbel, L. M.; Kesten, S. J.; Turner, W. R.
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 11 p. 837 - 852
反应条件
1: 87 percent / pyridine / 0.33 h / Heating
2: 63 percent / aq. HCl / dioxane / 3 h / Heating
3: 98.4 g / polyphosphoric acid / 45 h / 110 °C
View Scheme
参考文献
Werbel, L. M.; Kesten, S. J.; Turner, W. R.
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 11 p. 837 - 852
反应条件
1: 37 percent / AcOH / 22 h / Heating
2: 87 percent / pyridine / 0.33 h / Heating
3: 63 percent / aq. HCl / dioxane / 3 h / Heating
4: 98.4 g / polyphosphoric acid / 45 h / 110 °C
View Scheme
参考文献
Werbel, L. M.; Kesten, S. J.; Turner, W. R.
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 11 p. 837 - 852
