6-氯-2,3-二氢喹啉-4-酮合成路线 （共 13 条）
反应条件
1: 6-chloro-2,3-dihydroquinolin-4(1H)-one With sodium hydride in N,N-dimethyl-formamide; mineral oil T=20°C; Inert atmosphere; 2: methyl iodide in N,N-dimethyl-formamide; mineral oil T=80°C;
参考文献
Fang, Yuesi; Rogness, Donald C.; Larock, Richard C.; Shi, Feng
Journal of Organic Chemistry, 2012 , vol. 77, # 14 p. 6262 - 6270
反应条件
trifluorormethanesulfonic acid in 1,2-dichloro-ethane
T=0 - 20°C; 0.25 h;
参考文献
Anderson, Kevin W.; Tepe, Jetze J.
Organic Letters, 2002 , vol. 4, # 3 p. 459 - 461
反应条件
trichlorophosphate
T=100°C; Erhitzen des Reaktionsprodukts mit einem Gemisch von Essigsaeure und konz.wss.Salzsaeure.;
参考文献
Hurd; Hayao
Journal of the American Chemical Society, 1954 , vol. 76, p. 5065,5067
Full Text Show Details
Elderfield; Maggiolo
Journal of the American Chemical Society, 1949 , vol. 71, p. 1906,1910
反应条件
trifluorormethanesulfonic acid
T=0 - 20°C; 0.25 h;
参考文献
Anderson, Kevin W.; Tepe, Jetze J.
Tetrahedron, 2002 , vol. 58, # 42 p. 8475 - 8481
反应条件
1: acetic acid
2: aqueous NaOH-solution
3: benzene; pyridine
4: phosphoryl chloride / 100 °C / Erhitzen des Reaktionsprodukts mit einem Gemisch von Essigsaeure und konz.wss.Salzsaeure.
View Scheme
参考文献
Elderfield; Maggiolo
Journal of the American Chemical Society, 1949 , vol. 71, p. 1906,1910
反应条件
1: 35 percent / ethylmagnesium bromide / tetrahydrofuran / 14 h
2: 30 percent / trifluoroacetic acid / 1.5 h / 100 °C
View Scheme
参考文献
Kano, Shinzo; Ebata, Tsutomu; Shibuya, Shiroshi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 2105 - 2111
反应条件
1: benzene; pyridine
2: phosphoryl chloride / 100 °C / Erhitzen des Reaktionsprodukts mit einem Gemisch von Essigsaeure und konz.wss.Salzsaeure.
View Scheme
参考文献
Elderfield; Maggiolo
Journal of the American Chemical Society, 1949 , vol. 71, p. 1906,1910
反应条件
1: copper(l) iodide; potassium carbonate / toluene / 20 h / 18 - 140 °C / Inert atmosphere; Sealed
2: trifluorormethanesulfonic acid / dichloromethane / 1 h / 0 - 18 °C / Inert atmosphere
View Scheme
参考文献
Lange, Jens; Bissember, Alex C.; Banwell, Martin G.; Cade, Ian A.
Australian Journal of Chemistry, 2011 , vol. 64, # 4 p. 454 - 470
反应条件
1: sodium t-butanolate / N,N-dimethyl-formamide / 0 - 20 °C
2: trifluorormethanesulfonic acid / 1,2-dichloro-ethane / 0 - 20 °C
View Scheme
参考文献
Fang, Yuesi; Rogness, Donald C.; Larock, Richard C.; Shi, Feng
Journal of Organic Chemistry, 2012 , vol. 77, # 14 p. 6262 - 6270
反应条件
hydrogenchloride; water
参考文献
Braunholtz; Mann
Journal of the Chemical Society, 1954 , p. 651,657
