5-[(3,4-二羟基苯基)甲基]二氢-2(3H)-呋喃酮合成路线 （共 10 条）
反应条件
boron tribromide in dichloromethane T=-78 - 0°C;
参考文献
Lambert, Joshua D.; Rice, Joseph E.; Hong, Jungil; Hou, Zhe; Yang, Chung S.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 4 p. 873 - 876
反应条件
1.1: Pd(OAc)2; PPh3; Ag2CO3 / acetonitrile / Heating 1.2: mCPBA; aq. NaHCO3 / CH2Cl2 1.3: H2 / Pd/C 2.1: 98 percent / KOH / methanol 3.1: 100 percent / CuSO4 / benzene / Heating 4.1: 34 percent / BBr3 / CH2Cl2 / -78 - 0 °C View Scheme
参考文献
Lambert, Joshua D.; Rice, Joseph E.; Hong, Jungil; Hou, Zhe; Yang, Chung S.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 4 p. 873 - 876
反应条件
1.1: (COCl)2 2.1: Pd(OAc)2; PPh3; Ag2CO3 / acetonitrile / Heating 2.2: mCPBA; aq. NaHCO3 / CH2Cl2 2.3: H2 / Pd/C 3.1: 98 percent / KOH / methanol 4.1: 100 percent / CuSO4 / benzene / Heating 5.1: 34 percent / BBr3 / CH2Cl2 / -78 - 0 °C View Scheme
参考文献
Lambert, Joshua D.; Rice, Joseph E.; Hong, Jungil; Hou, Zhe; Yang, Chung S.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 4 p. 873 - 876
反应条件
1.1: Pd(OAc)2; PPh3; Ag2CO3 / acetonitrile / Heating 1.2: mCPBA; aq. NaHCO3 / CH2Cl2 1.3: H2 / Pd/C 2.1: 98 percent / KOH / methanol 3.1: 100 percent / CuSO4 / benzene / Heating 4.1: 34 percent / BBr3 / CH2Cl2 / -78 - 0 °C View Scheme
参考文献
Lambert, Joshua D.; Rice, Joseph E.; Hong, Jungil; Hou, Zhe; Yang, Chung S.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 4 p. 873 - 876
反应条件
1.1: 46 percent / ICl / CH2Cl2 / 0 °C 2.1: Pd(OAc)2; PPh3; Ag2CO3 / acetonitrile / Heating 2.2: mCPBA; aq. NaHCO3 / CH2Cl2 2.3: H2 / Pd/C 3.1: 98 percent / KOH / methanol 4.1: 100 percent / CuSO4 / benzene / Heating 5.1: 34 percent / BBr3 / CH2Cl2 / -78 - 0 °C View Scheme
参考文献
Lambert, Joshua D.; Rice, Joseph E.; Hong, Jungil; Hou, Zhe; Yang, Chung S.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 4 p. 873 - 876
反应条件
1.1: Pd(OAc)2; PPh3; Ag2CO3 / acetonitrile / Heating 1.2: mCPBA; aq. NaHCO3 / CH2Cl2 1.3: H2 / Pd/C 2.1: 98 percent / KOH / methanol 3.1: 100 percent / CuSO4 / benzene / Heating 4.1: 34 percent / BBr3 / CH2Cl2 / -78 - 0 °C View Scheme
参考文献
Lambert, Joshua D.; Rice, Joseph E.; Hong, Jungil; Hou, Zhe; Yang, Chung S.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 4 p. 873 - 876
反应条件
1.1: 97 percent / pyridine 2.1: 46 percent / ICl / CH2Cl2 / 0 °C 3.1: Pd(OAc)2; PPh3; Ag2CO3 / acetonitrile / Heating 3.2: mCPBA; aq. NaHCO3 / CH2Cl2 3.3: H2 / Pd/C 4.1: 98 percent / KOH / methanol 5.1: 100 percent / CuSO4 / benzene / Heating 6.1: 34 percent / BBr3 / CH2Cl2 / -78 - 0 °C View Scheme
参考文献
Lambert, Joshua D.; Rice, Joseph E.; Hong, Jungil; Hou, Zhe; Yang, Chung S.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 4 p. 873 - 876
反应条件
1: 100 percent / CuSO4 / benzene / Heating 2: 34 percent / BBr3 / CH2Cl2 / -78 - 0 °C View Scheme
参考文献
Lambert, Joshua D.; Rice, Joseph E.; Hong, Jungil; Hou, Zhe; Yang, Chung S.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 4 p. 873 - 876
反应条件
1: 98 percent / KOH / methanol 2: 100 percent / CuSO4 / benzene / Heating 3: 34 percent / BBr3 / CH2Cl2 / -78 - 0 °C View Scheme
参考文献
Lambert, Joshua D.; Rice, Joseph E.; Hong, Jungil; Hou, Zhe; Yang, Chung S.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 4 p. 873 - 876
反应条件
hydrogen bromide in acetic acid demethylation; 1 h; Heating;
参考文献
Dueweler, K. Grosse; Rohdewald
Pharmazie, 2000 , vol. 55, # 5 p. 364 - 368
