hydrogen; palladium dihydroxide in methanol P=759.8 Torr; 16 h; Ambient temperature;

1.1: 28 percent / α-chymotrypsine (α-CT) / aq. phosphate buffer / 20 °C / pH 7.4 / low conversion 2.1: BH3-DMS / tetrahydrofuran / -10 - 20 °C 2.2: aq. HCl / tetrahydrofuran; methanol / 1 h / Heating 3.1: H2 / 20 percent Pd(OH)2/C / methanol / 20 °C View Scheme

1.1: 85 percent / methanol / 12 h / 20 °C 2.1: 28 percent / α-chymotrypsine (α-CT) / aq. phosphate buffer / 20 °C / pH 7.4 / low conversion 3.1: BH3-DMS / tetrahydrofuran / -10 - 20 °C 3.2: aq. HCl / tetrahydrofuran; methanol / 1 h / Heating 4.1: H2 / 20 percent Pd(OH)2/C / methanol / 20 °C View Scheme

1.1: BH3-DMS / tetrahydrofuran / -10 - 20 °C 1.2: aq. HCl / tetrahydrofuran; methanol / 1 h / Heating 2.1: H2 / 20 percent Pd(OH)2/C / methanol / 20 °C View Scheme

1.1: BH3-DMS / tetrahydrofuran / -10 - 20 °C 1.2: aq. HCl / tetrahydrofuran; methanol / 1 h / Heating 2.1: H2 / 20 percent Pd(OH)2/C / methanol / 20 °C View Scheme

1: HCl, H2O / 0.5 h / Heating 2: SOCl2 / 1.) -50 deg C to room temp., 3 h, 2.) room temp., 11 h 3: 73 percent / H2 / 20percent Pd(OH)2/C / methanol / 16 h / 759.8 Torr / Ambient temperature View Scheme