2-吡啶-4-基-1-间甲苯乙酮合成路线 （共 7 条）
反应条件
1: 4-Methylpyridine With lithium diisopropyl amide in tetrahydrofuran; hexane T=-10°C; 0.333333 h; 2: 1-(3-methylbenzoyl)-2-methylaziridine in tetrahydrofuran; hexane T=-78°C; 1 h;
参考文献
Miwatashi, Seiji; Arikawa, Yasuyoshi; Kotani, Etsuo; Miyamoto, Maki; Naruo, Ken-Ichi; Kimura, Hiroyuki; Tanaka, Toshimasa; Asahi, Satoru; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5966 - 5979
反应条件
in tetrahydrofuran T=-78°C; 3 h;
参考文献
ALLERGAN, INC.
Patent: US2007/270498 A1, 2007 ;
Location in patent: Page/Page column 24 ;
反应条件
sodium hexamethyldisilazane in tetrahydrofuran T=-78 - 20°C; 16 h;
参考文献
G.D. Searle and Company
Patent: US6342608 B1, 2002 ;
Location in patent: Example 1 ;
US 6342608 B1
参考文献
G. D. Searle and Company
Patent: US6423713 B1, 2002 ;
US 6423713 B1
Title/Abstract Full Text Show Details
G.D. Searle and Company
Patent: US6514977 B1, 2003 ;
US 6514977 B1
反应条件
1.1: 100 percent / aq. NaOH / diethyl ether / 0 °C 2.1: LDA / tetrahydrofuran; hexane / 0.33 h / -10 °C 2.2: 65 percent / tetrahydrofuran; hexane / 1 h / -78 °C View Scheme
参考文献
Miwatashi, Seiji; Arikawa, Yasuyoshi; Naruo, Ken-Ichi; Igaki, Keiko; Watanabe, Yasumasa; Kimura, Hiroyuki; Kawamoto, Tomohiro; Ohkawa, Shigenori
Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 4 p. 410 - 418
反应条件
1: Br2; AcOH / 3 h / 80 °C 2: 84 percent / dimethylformamide / 14 h / 20 °C View Scheme
参考文献
Miwatashi, Seiji; Arikawa, Yasuyoshi; Naruo, Ken-Ichi; Igaki, Keiko; Watanabe, Yasumasa; Kimura, Hiroyuki; Kawamoto, Tomohiro; Ohkawa, Shigenori
Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 4 p. 410 - 418
反应条件
1: Br2; AcOH / 3 h / 80 °C
2: 59 percent / dimethylformamide / 14 h / 20 °C
3: 74 percent / mCPBA / dimethylformamide / 14 h / 20 °C
View Scheme
参考文献
Miwatashi, Seiji; Arikawa, Yasuyoshi; Naruo, Ken-Ichi; Igaki, Keiko; Watanabe, Yasumasa; Kimura, Hiroyuki; Kawamoto, Tomohiro; Ohkawa, Shigenori
Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 4 p. 410 - 418
