(2R,5S)-1-苄基-2,5-二甲基哌嗪合成路线 （共 6 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 70°C; 24 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2005/40136 A1, 2005 ;
Location in patent: Page/Page column 78-79 ;
WO 2005/040136 A1
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=80°C; 5.66667 h; Cooling with iceInert atmosphere;
参考文献
KOWA COMPANY, LTD.
Patent: US2010/280013 A1, 2010 ;
Location in patent: Page/Page column 28 ;
参考文献
WO2008/96260 A1, ;
Page/Page column 41 ;
WO 2008/096260 A1
反应条件
1: ethanol 2: via the salt with (-)-tartaric acid View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 2 p. 236 - 249
反应条件
1: ethanol 2: via the salt with (-)-tartaric acid View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 2 p. 236 - 249
参考文献
Journal of Medicinal Chemistry, , vol. 42, # 15 p. 2741 - 2746
