3-氯-4,4-二甲基戊-2-烯腈合成路线 （共 7 条）
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate T=0 - 20°C; 2: 3,3-dimethyl-butan-2-one T=40 - 75°C; 4 h; 3: With hydroxylamine hydrochloride T=20 - 85°C;
参考文献
Bayer Corporation
Patent: EP1019040 B1, 2004 ;
Location in patent: Page/Page column 28-29 ;
反应条件
1: 61 percent / POCl3 / 5 h / 60 °C 2: NH2OH*HCl / dimethylformamide / 8 h / 110 °C 3: Ac2O / 18 h / Heating View Scheme
参考文献
Synthesis, , # 8 p. 1096 - 1100
反应条件
1: NH2OH*HCl / dimethylformamide / 8 h / 110 °C 2: Ac2O / 18 h / Heating View Scheme
参考文献
Synthesis, , # 8 p. 1096 - 1100
反应条件
1: oxyacetic acid methyl ester With sodium hydride in ethylene glycol dimethyl ether T=0 - 20°C; 1.33333 h; 2: 3-chloro-4,4-dimethylpent-2-enenitrile in ethylene glycol dimethyl ether T=85°C; 42 h;
参考文献
Bayer Corporation
Patent: EP1019040 B1, 2004 ;
Location in patent: Page/Page column 29 ;
反应条件
1.1: sodium sulfide / N,N-dimethyl-formamide / 2 h / 70 - 80 °C 1.2: 2 h / 70 - 80 °C 1.3: 2 h / 70 - 80 °C 2.1: sodium hydroxide / ethanol; water / 1 h / Reflux View Scheme
参考文献
KASINA LAILA INNOVA PHARMACEUTICALS PRIVATE LIMITED; GOKARAJU, Ganga Raju; KASINA, Sudhakar; SOMEPALLI, Venkateswarlu; GOKARAJU, Rama Raju; GOKARAJU, Venkata Kanaka Ranga Raju; BHUPATHIRAJU, Kiran; GOLAKOTI, Trimurtulu; SENGUPTA, Krishanu; ALLURI, Venkata Krishna Raju
Patent: WO2012/77135 A2, 2012 ;
WO 2012/077135 A2
反应条件
potassium carbonate in tetrahydrofuran; methanol Heating;
参考文献
Migianu, Evelyne; Kirsch, Gilbert
Synthesis, 2002 , # 8 p. 1096 - 1100
反应条件
1: 3-chloro-4,4-dimethylpent-2-enenitrile With sodium sulfide in N,N-dimethyl-formamide
T=70 - 80°C; 2 h;
2: chloroacetonitrile in N,N-dimethyl-formamide
T=70 - 80°C; 2 h;
3: With sodium methylate in methanol; N,N-dimethyl-formamide
T=70 - 80°C; 2 h;
参考文献
KASINA LAILA INNOVA PHARMACEUTICALS PRIVATE LIMITED; GOKARAJU, Ganga Raju; KASINA, Sudhakar; SOMEPALLI, Venkateswarlu; GOKARAJU, Rama Raju; GOKARAJU, Venkata Kanaka Ranga Raju; BHUPATHIRAJU, Kiran; GOLAKOTI, Trimurtulu; SENGUPTA, Krishanu; ALLURI, Venkata Krishna Raju
Patent: WO2012/77135 A2, 2012 ;
Location in patent: Page/Page column 75-76 ;
WO 2012/077135 A2
