6-羟基-2,3-二氢-1H-茚-1-羧酸甲酯合成路线 （共 3 条）
反应条件
1: With boron tribromide in dichloromethane T=20°C; 1.5 h; Cooling with ice-water; 2: With water in dichloromethane
参考文献
BIOGEN IDEC MA INC; PENG, Hairuo; CUERVO, Julio, H.; ISHCHENKO, Alexey; KUMARAVEL, Gnanasambandam; LEE, Wen-cherng; LUGOVSKOY, Alexey; TALREJA, Tina; TAVERAS, Arthur, G.; XIN, Zhili
Patent: WO2010/138901 A1, 2010 ;
Location in patent: Page/Page column 153-154 ;
WO 2010/138901 A1
反应条件
thionyl chloride T=20°C; 72 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/157270 A1, 2008 ;
Location in patent: Page/Page column 70 ;
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexanes / 1 h / -15 °C 1.2: 3 h / -15 - 20 °C 1.3: 1.5 h / Reflux 2.1: hydrogenchloride; water; acetic acid / 16 h / Reflux 2.2: 24 h / Reflux 3.1: thionyl chloride / 72 h / 20 °C View Scheme
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/157270 A1, 2008 ;
