6-苯基-3(2H)-哒嗪酮合成路线 （共 69 条）
反应条件
1: phosphorus oxychloride / 4 h / 85 - 95 °C 2: hydrazine hydrate / butan-1-ol / 6 h / 100 °C 3: H2 / Raney Ni / methanol / 20 °C / 760 Torr View Scheme
参考文献
Wermuth, Camille-Georges; Bourguignon, Jean-Jacques; Schlewer, Gilbert; Gies, Jean-Pierre; Schoenfelder, Angele; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 239 - 249
反应条件
trichlorophosphate T=100°C; 2 h;
参考文献
Kuemmerle, Arthur E.; Vieira, Marina M.; Schmitt, Martine; Miranda, Ana L.P.; Fraga, Carlos A.M.; Bourguignon, Jean-Jacques; Barreiro, Eliezer J.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 17 p. 4963 - 4966
参考文献
Gabriel; Colman
Chemische Berichte, 1899 , vol. 32, p. 398
反应条件
1: POCl3, N,N-Dimethylaniline / 7 h / 130 °C
2: 38 percent / sodium acetate, hydrogen / 10percent palladium on carbon / ethanol / 760 Torr
View Scheme
参考文献
Shkurko, O. P.; Kuznetsov, S. A.; Denisov, A. Yu.; Mamaev, V. P.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1986 , vol. 22, # 7 p. 763 - 770
Khimiya Geterotsiklicheskikh Soedinenii, 1986 , vol. 22, # 7 p. 951 - 958
反应条件
C20H10Cl2CuN2O8S2(2-)*2Na(1+); sodium carbonate in water
T=20 - 80°C; 12 h; Sealed tube;
参考文献
Liang, Lei; Wang, Wei; Wu, Jun; Xu, Fengrong; Niu, Yan; Xu, Bo; Xu, Ping
Chemistry - A European Journal, 2013 , vol. 19, # 41 p. 13774 - 13782
反应条件
1: 85 percent / K2CO3 / various solvent(s) / 6 h / Heating
2: 1.) 100 percent hydrazine hydrate, 2.) 10 percent aq. HCl / 1.) EtOH, reflux, 4 h, 2.) EtOH, reflux, 2 h
View Scheme
参考文献
Yamada; Tsukamoto; Shimamura; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 3 p. 209 - 214
反应条件
1: 78 percent / tetra-n-butylammonium bromide, potassium hydroxyde / benzene / 6 h / Ambient temperature
2: 79 percent / 1.) 100percent hydrazine hydrate; 2.) aq. 10percent hydrochloric / ethanol / 1.) reflux, 5 h; 2.) pH=4.0, reflux, 2 h
3: 37 percent / triethylamine / benzene
View Scheme
参考文献
Yamada; Tsukamoto; Shimamura; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 3 p. 209 - 214
反应条件
1: 78 percent / tetra-n-butylammonium bromide, potassium hydroxyde / benzene / 6 h / Ambient temperature
2: 79 percent / 1.) 100percent hydrazine hydrate; 2.) aq. 10percent hydrochloric / ethanol / 1.) reflux, 5 h; 2.) pH=4.0, reflux, 2 h
3: 66 percent / triethylamine / benzene / 2 h / Heating
View Scheme
参考文献
Yamada; Tsukamoto; Shimamura; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 3 p. 209 - 214
反应条件
1: 87 percent / tetra-n-butylammonium bromide, potassium hydroxyde / benzene / 6 h / Ambient temperature
2: 87 percent / 1.) 100percent hydrazine hydrate; 2.) aq. 10percent hydrochloric / ethanol / 1.) reflux, 5 h; 2.) pH=4.0, reflux, 2 h
3: 86 percent / CHCl3 / 2 h / Heating
View Scheme
参考文献
Yamada; Tsukamoto; Shimamura; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 3 p. 209 - 214
反应条件
1: 87 percent / tetra-n-butylammonium bromide, potassium hydroxyde / benzene / 6 h / Ambient temperature
2: 87 percent / 1.) 100percent hydrazine hydrate; 2.) aq. 10percent hydrochloric / ethanol / 1.) reflux, 5 h; 2.) pH=4.0, reflux, 2 h
3: 83 percent / CHCl3
View Scheme
参考文献
Yamada; Tsukamoto; Shimamura; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 3 p. 209 - 214
