6-苯基-3(2H)-哒嗪酮合成路线 （共 69 条）
反应条件
1: 76 percent / tetra-n-butylammonium bromide, potassium hydroxyde / benzene / 6 h / Ambient temperature
2: 93 percent / 1.) 100percent hydrazine hydrate; 2.) aq. 10percent hydrochloric / ethanol / 1.) reflux, 5 h; 2.) pH=4.0, reflux, 2 h
3: 52 percent / CHCl3 / 2 h / Heating
View Scheme
参考文献
Yamada; Tsukamoto; Shimamura; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 3 p. 209 - 214
反应条件
1: 76 percent / tetra-n-butylammonium bromide, potassium hydroxyde / benzene / 6 h / Ambient temperature
2: 93 percent / 1.) 100percent hydrazine hydrate; 2.) aq. 10percent hydrochloric / ethanol / 1.) reflux, 5 h; 2.) pH=4.0, reflux, 2 h
3: 79 percent / CHCl3
View Scheme
参考文献
Yamada; Tsukamoto; Shimamura; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 3 p. 209 - 214
反应条件
1: 76 percent / tetra-n-butylammonium bromide, potassium hydroxyde / benzene / 6 h / Ambient temperature
2: 93 percent / 1.) 100percent hydrazine hydrate; 2.) aq. 10percent hydrochloric / ethanol / 1.) reflux, 5 h; 2.) pH=4.0, reflux, 2 h
3: 59 percent / triethylamine / benzene
View Scheme
参考文献
Yamada; Tsukamoto; Shimamura; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 3 p. 209 - 214
反应条件
1: 76 percent / tetra-n-butylammonium bromide, potassium hydroxyde / benzene / 6 h / Ambient temperature
2: 93 percent / 1.) 100percent hydrazine hydrate; 2.) aq. 10percent hydrochloric / ethanol / 1.) reflux, 5 h; 2.) pH=4.0, reflux, 2 h
3: 30 percent / triethylamine / benzene
View Scheme
参考文献
Yamada; Tsukamoto; Shimamura; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 3 p. 209 - 214
反应条件
1: 52 percent / potassium hydroxide, tetra-n-butylammonium bromide / benzene / 6 h / Ambient temperature
2: 75 percent / 25percent ammonium hydroxide / ethanol / 24 h / 40 °C
3: 59 percent / CHCl3 / 2 h / Heating
View Scheme
参考文献
Yamada; Tsukamoto; Shimamura; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 3 p. 209 - 214
反应条件
1: 47 percent / potassium hydroxide, tetra-n-butylammonium bromide / benzene / 6 h / Ambient temperature
2: 47 percent / 25percent ammonium hydroxide / ethanol / 24 h / 40 °C
3: 51 percent / CHCl3
View Scheme
参考文献
Yamada; Tsukamoto; Shimamura; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 3 p. 209 - 214
反应条件
1: 49 percent / potassium hydroxide, tetra-n-butylammonium bromide / benzene / 6 h / Ambient temperature
2: 49 percent / 25percent ammonium hydroxide / ethanol / 24 h / 40 °C
3: 34 percent / CHCl3
View Scheme
参考文献
Yamada; Tsukamoto; Shimamura; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 3 p. 209 - 214
反应条件
1: 42 percent / potassium hydroxide, tetra-n-butylammonium bromide / benzene / 6 h / Ambient temperature
2: 46 percent / 25percent ammonium hydroxide / ethanol / 24 h / 40 °C
3: 28 percent / CHCl3
View Scheme
参考文献
Yamada; Tsukamoto; Shimamura; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 3 p. 209 - 214
反应条件
1: 81 percent / tetra-n-butylammonium bromide, potassium hydroxyde / benzene / 6 h / Ambient temperature
2: 83 percent / 1.) 100percent hydrazine hydrate; 2.) aq. 10percent hydrochloric / ethanol / 1.) reflux, 5 h; 2.) pH=4.0, reflux, 2 h
3: 45 percent / aq. acetic acid
View Scheme
参考文献
Yamada; Tsukamoto; Shimamura; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 3 p. 209 - 214
反应条件
1: 81 percent / tetra-n-butylammonium bromide, potassium hydroxyde / benzene / 6 h / Ambient temperature
2: 83 percent / 1.) 100percent hydrazine hydrate; 2.) aq. 10percent hydrochloric / ethanol / 1.) reflux, 5 h; 2.) pH=4.0, reflux, 2 h
3: 89 percent / CHCl3
View Scheme
参考文献
Yamada; Tsukamoto; Shimamura; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 3 p. 209 - 214
