6-苯基-3(2H)-哒嗪酮合成路线 （共 69 条）
反应条件
1: 78 percent / tetra-n-butylammonium bromide, potassium hydroxyde / benzene / 6 h / Ambient temperature
2: 79 percent / 1.) 100percent hydrazine hydrate; 2.) aq. 10percent hydrochloric / ethanol / 1.) reflux, 5 h; 2.) pH=4.0, reflux, 2 h
3: 21 percent / aq. acetic acid
View Scheme
参考文献
Yamada; Tsukamoto; Shimamura; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 3 p. 209 - 214
反应条件
1: 78 percent / tetra-n-butylammonium bromide, potassium hydroxyde / benzene / 6 h / Ambient temperature
2: 79 percent / 1.) 100percent hydrazine hydrate; 2.) aq. 10percent hydrochloric / ethanol / 1.) reflux, 5 h; 2.) pH=4.0, reflux, 2 h
3: 83 percent / CHCl3
View Scheme
参考文献
Yamada; Tsukamoto; Shimamura; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 3 p. 209 - 214
反应条件
1: 78 percent / tetra-n-butylammonium bromide, potassium hydroxyde / benzene / 6 h / Ambient temperature
2: 79 percent / 1.) 100percent hydrazine hydrate; 2.) aq. 10percent hydrochloric / ethanol / 1.) reflux, 5 h; 2.) pH=4.0, reflux, 2 h
3: 94 percent / CHCl3
View Scheme
参考文献
Yamada; Tsukamoto; Shimamura; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 3 p. 209 - 214
反应条件
1: 78 percent / tetra-n-butylammonium bromide, potassium hydroxyde / benzene / 6 h / Ambient temperature
2: 79 percent / 1.) 100percent hydrazine hydrate; 2.) aq. 10percent hydrochloric / ethanol / 1.) reflux, 5 h; 2.) pH=4.0, reflux, 2 h
3: 64 percent / CHCl3
View Scheme
参考文献
Yamada; Tsukamoto; Shimamura; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 3 p. 209 - 214
反应条件
1: 78 percent / tetra-n-butylammonium bromide, potassium hydroxyde / benzene / 6 h / Ambient temperature
2: 79 percent / 1.) 100percent hydrazine hydrate; 2.) aq. 10percent hydrochloric / ethanol / 1.) reflux, 5 h; 2.) pH=4.0, reflux, 2 h
3: 50 percent / triethylamine / benzene / 2 h / Heating
View Scheme
参考文献
Yamada; Tsukamoto; Shimamura; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 3 p. 209 - 214
反应条件
1: 87 percent / tetra-n-butylammonium bromide, potassium hydroxyde / benzene / 6 h / Ambient temperature
2: 87 percent / 1.) 100percent hydrazine hydrate; 2.) aq. 10percent hydrochloric / ethanol / 1.) reflux, 5 h; 2.) pH=4.0, reflux, 2 h
3: 18 percent / aq. acetic acid / 2 h / 50 - 55 °C
View Scheme
参考文献
Yamada; Tsukamoto; Shimamura; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 3 p. 209 - 214
反应条件
1: 70 percent / Na / ethanol / 24 h / Heating
2: aq. HCl
View Scheme
参考文献
Strappaghetti, Giovannella; Corsano, Stefano; Barbaro, Roberta; Giannaccini, Gino; Betti, Laura
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 3 p. 575 - 583
反应条件
potassium hydroxide; tetrabutylammomium bromide in benzene
8 h; Ambient temperature;
参考文献
Yamada, Toshihiro; Ohki, Masahiko
Synthesis, 1981 , # 8 p. 631 - 633
参考文献
Morishita Pharmaceutical Co., Ltd.
Patent: US4242512 A1, 1980 ;
