6-(4-甲氧基苯基)吡嗪-3(2H)-酮合成路线 （共 10 条）
反应条件
copper dichloride in acetonitrile 0.25 h; Heating;
参考文献
Csende; Szabo; Bernath; Stajer
Synthesis, 1995 , # 10 p. 1240 - 1242
反应条件
ammonium hydroxide; hydrazine hydrate 1) 100-105 deg C, 2 h, 2) water, 2 h, reflux; Yield given. Multistep reaction;
参考文献
Synthesis, , # 3 p. 334 - 342
反应条件
1: copper(II) oxide; iodine / dimethyl sulfoxide / 12 h / 70 °C 2: hydrazine hydrate / tert-butyl alcohol / |Reflux View Scheme
参考文献
Journal of Organic Chemistry, , vol. 77, # 21 p. 9865 - 9870,6
反应条件
1: N2H4*H2O / ethanol / 4 h / Heating 2: Br2 / acetic acid / 3 h / Heating View Scheme
参考文献
Archiv der Pharmazie, , vol. 333, # 4 p. 79 - 86
反应条件
hydrazine hydrate in tert-butyl alcohol Reflux;
参考文献
Gao, Qinghe; Zhu, Yanping; Lian, Mi; Liu, Meicai; Yuan, Jingjing; Wu, Anxin; Yin, Guodong
Journal of Organic Chemistry, 2012 , vol. 77, # 21 p. 9865 - 9870,6
反应条件
1: trifluoroacetic acid / dichloromethane / 16 h 2: hydrazine hydrate / ethanol / 2.5 h / |Reflux 3: sodium hydroxide; m-nitrobenzene sulfonic acid sodium salt / water / 1.5 h / |Reflux View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 1 p. 375 - 381
反应条件
trichlorophosphate T=0°C; 6 h; Heating / reflux;
参考文献
BANYU PHARMACEUTICAL CO., LTD.
Patent: EP1719756 A1, 2006 ;
Location in patent: Page/Page column 43 ;
EP 1719756 A1
反应条件
1: phosphorus oxychloride / 4 h / 85 - 95 °C 2: hydrazine hydrate / butan-1-ol / 6 h / 100 °C 3: H2 / Raney Ni / methanol / 20 °C / 760 Torr View Scheme
参考文献
Wermuth, Camille-Georges; Bourguignon, Jean-Jacques; Schlewer, Gilbert; Gies, Jean-Pierre; Schoenfelder, Angele; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 239 - 249
反应条件
1: phosphorus oxychloride / 4 h / 85 - 95 °C 2: hydrazine hydrate / butan-1-ol / 6 h / 100 °C View Scheme
参考文献
Wermuth, Camille-Georges; Bourguignon, Jean-Jacques; Schlewer, Gilbert; Gies, Jean-Pierre; Schoenfelder, Angele; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 239 - 249
反应条件
AlCl3, aluminium chloride in dichloromethane
T=20°C; 19 h;
参考文献
Ochiai, Koji; Takita, Satoshi; Kojima, Akihiko; Eiraku, Tomohiko; Iwase, Kazuhiko; Kishi, Tetsuya; Ohinata, Akira; Yageta, Yuichi; Yasue, Tokutaro; Adams, David R.; Kohno, Yasushi
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 1 p. 375 - 381
