4-氯-2-[2-[3-氯苯基]乙基]苯甲酸合成路线 （共 4 条）
反应条件
1: 4-chloro-2-methylbenzoic acid With sec.-butyllithium in tetrahydrofuran; hexane T=-60 - -30°C; 1 h; 2: 3-chlorophenylmethyl bromide in tetrahydrofuran; hexane T=-40 - 20°C; 4 h;
参考文献
ALANTOS PHARMACEUTICALS, INC.
Patent: WO2006/116157 A2, 2006 ;
Location in patent: Page/Page column 97-98 ;
WO 2006/116157 A2
反应条件
palladium 10 on activated carbon; hydrogen in methanol T=20°C; P=760.051 Torr; 1 h;
参考文献
Takahashi, Chika; Mikamiyama, Hidenori; Akiyama, Toshiyuki; Tomita, Kenji; Taoda, Yoshiyuki; Kawai, Makoto; Anan, Kosuke; Miyagawa, Masayoshi; Suzuki, Naoyuki
Patent: US2013/197219 A1, 2013 ;
Location in patent: Paragraph 1644; 1649; 1650 ;
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C 2: triethylamine; copper(l) chloride; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 5 h / 20 °C / |Inert atmosphere 3: palladium 10 on activated carbon; hydrogen / methanol / 1 h / 20 °C / 760.05 Torr View Scheme
参考文献
Takahashi, Chika; Mikamiyama, Hidenori; Akiyama, Toshiyuki; Tomita, Kenji; Taoda, Yoshiyuki; Kawai, Makoto; Anan, Kosuke; Miyagawa, Masayoshi; Suzuki, Naoyuki
Patent: US2013/197219 A1, 2013 ;
反应条件
1: triethylamine; copper(l) chloride; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 5 h / 20 °C / |Inert atmosphere 2: palladium 10 on activated carbon; hydrogen / methanol / 1 h / 20 °C / 760.05 Torr View Scheme
参考文献
Takahashi, Chika; Mikamiyama, Hidenori; Akiyama, Toshiyuki; Tomita, Kenji; Taoda, Yoshiyuki; Kawai, Makoto; Anan, Kosuke; Miyagawa, Masayoshi; Suzuki, Naoyuki
Patent: US2013/197219 A1, 2013 ;
