1-乙基-1H-吡咯-2-甲醛合成路线 （共 10 条）
反应条件
caesium carbonate in acetone
Reflux;
参考文献
Buckman, Brad Owen; Nicholas, John Beamond; Ramphal, Johnnie Y.; Emayan, Kumaraswamy; Seiwert, Scott D.
Patent: US2014/94456 A1, 2014 ;
Location in patent: Paragraph 0838-0839 ;
反应条件
1: 1H-pyrrole-2-carboxaldehyde With potassium hydroxide in dimethyl sulfoxide
T=20°C; 0.75 h;
2: ethyl bromide in dimethyl sulfoxide
0.75 h; cooling; Further stages.;
参考文献
Soares, Maria I.L.; Lopes, Susana M.M.; Cruz, Pedro F.; Brito, Rui M.M.; Pinho e Melo, Teresa M.V.D.
Tetrahedron, 2008 , vol. 64, # 41 p. 9745 - 9753
反应条件
tri-n-butyl-tin hydride in cyclohexane; acetonitrile
T=80°C;
参考文献
Allin, Steven M.; Barton, William R.S.; Bowman; McInally, Tom
Tetrahedron Letters, 2001 , vol. 42, # 44 p. 7887 - 7890
反应条件
2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride in cyclohexane
Heating;
参考文献
Allin, Steven M.; Barton, William R.S.; Bowman; McInally, Tom
Tetrahedron Letters, 2001 , vol. 42, # 44 p. 7887 - 7890
反应条件
1.1: NaH / dimethylformamide / 0.5 h / 20 °C
1.2: 24 h / 20 °C
2.1: 73 percent / LiOH / aq. ethanol / 4 h / 20 °C
3.1: 59 percent / Bu3P / CH2Cl2 / 24 h / 20 °C
4.1: 34 percent / Bu3SnH; AIBN / cyclohexane / Heating
View Scheme
参考文献
Allin, Steven M.; Barton, William R.S.; Bowman; McInally, Tom
Tetrahedron Letters, 2001 , vol. 42, # 44 p. 7887 - 7890
反应条件
1: 59 percent / Bu3P / CH2Cl2 / 24 h / 20 °C
2: 34 percent / Bu3SnH; AIBN / cyclohexane / Heating
View Scheme
参考文献
Allin, Steven M.; Barton, William R.S.; Bowman; McInally, Tom
Tetrahedron Letters, 2001 , vol. 42, # 44 p. 7887 - 7890
反应条件
1: 73 percent / LiOH / aq. ethanol / 4 h / 20 °C
2: 59 percent / Bu3P / CH2Cl2 / 24 h / 20 °C
3: 34 percent / Bu3SnH; AIBN / cyclohexane / Heating
View Scheme
参考文献
Allin, Steven M.; Barton, William R.S.; Bowman; McInally, Tom
Tetrahedron Letters, 2001 , vol. 42, # 44 p. 7887 - 7890
反应条件
trichlorophosphate
Multistep reaction;
参考文献
Martinez, Gregory R.; Walker, Keith A. M.; Hirschfeld, Donald R.; Maloney, Patrick J.; Yang, Diana S.; Rosenkranz, Roberto P.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 890 - 897
反应条件
sodium hydride
1.) DMF, 2.) 125 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Mercey, Jacqueline M.; Toube, Trevor P.
Journal of Chemical Research, Miniprint, 1987 , # 3 p. 680 - 695
反应条件
Yield given. Multistep reaction;
参考文献
Comins, Daniel L.; Killpack, Michael O.
Journal of Organic Chemistry, 1987 , vol. 52, # 1 p. 104 - 109
