(Z)-4-十一烯-1-醇合成路线 （共 35 条）
反应条件
1: 78 percent / NaCl, H2O / dimethylsulfoxide / 8 h / 140 - 145 °C
2: 90 percent / LiAlH4 / diethyl ether / a.) reflux while adding reagent b.) room temperature overnight c.) 30 min reflux
View Scheme
参考文献
Vig, O. P.; Sharma, M. L.; Taneja, K. C.; Malik, Neera
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 10 p. 863 - 865
反应条件
1: 70 percent / benzene / 16 h / Heating
2: 78 percent / NaCl, H2O / dimethylsulfoxide / 8 h / 140 - 145 °C
3: 90 percent / LiAlH4 / diethyl ether / a.) reflux while adding reagent b.) room temperature overnight c.) 30 min reflux
View Scheme
参考文献
Vig, O. P.; Sharma, M. L.; Taneja, K. C.; Malik, Neera
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 10 p. 863 - 865
反应条件
methyl Grignard reagent; magnesium; [1,3-bis(diphenylphosphino) propane] dichloronickel(II)
1.) Et2O, 2.) C6H6, reflux, overnight; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Davis; Carlson
Synthesis, 1989 , # 12 p. 936 - 938
反应条件
dilithium tetrachlorocuprate in tetrahydrofuran
-30 gradC, 2 h, 0 gradC, 20 h; Yield given. Yields of byproduct given;
参考文献
Bac, Nguyen Van; Fall, Yagamare; Langlois, Yves
Tetrahedron Letters, 1986 , vol. 27, # 7 p. 841 - 844
反应条件
in tetrahydrofuran
-30 gradC, 0.5 h, -5 gradC, 20 h; Yield given. Yields of byproduct given;
参考文献
Bac, Nguyen Van; Fall, Yagamare; Langlois, Yves
Tetrahedron Letters, 1986 , vol. 27, # 7 p. 841 - 844
反应条件
dilithium tetrachlorocuprate in tetrahydrofuran
-30 gradC, 2 h, 0 gradC, 20 h; Yield given. Yields of byproduct given;
参考文献
Bac, Nguyen Van; Fall, Yagamare; Langlois, Yves
Tetrahedron Letters, 1986 , vol. 27, # 7 p. 841 - 844
反应条件
(i) nBuLi, (ii) /BRN= 1752419/, (iii) NaOH, aq. EtOH; Multistep reaction;
参考文献
Bergel'son,L.D. et al.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1968 , p. 2420 - 2424
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1968 , # 11 p. 2558 - 2563
反应条件
dilithium tetrachlorocuprate in tetrahydrofuran
-30 gradC, 2h, 0 gradC, 20h; organometallic educts, other temperature and reaction time; Product distribution;
参考文献
Bac, Nguyen Van; Fall, Yagamare; Langlois, Yves
Tetrahedron Letters, 1986 , vol. 27, # 7 p. 841 - 844
反应条件
(i) nBuLi, (ii) /BRN= 1752419/, (iii) NaOH, aq. EtOH; Multistep reaction;
参考文献
Bergel'son,L.D. et al.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1968 , p. 2420 - 2424
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1968 , # 11 p. 2558 - 2563
反应条件
1: 82 percent / PBr3, pyridine / diethyl ether / 1) rt, overnight, 2) reflux, 2 h
2: 1) Mg / 3) Li2CuCl4 / 1) THF, 2) THF, -10 deg C, 30 min, 3) a) 0 to -10 deg C, 6 h, b) rt, overnight
3: p-toluenesulphonic acid / methanol / 3 h / Heating
4: 68 percent / pyridine / 24 h / Ambient temperature
View Scheme
参考文献
Vig, O. P.; Sharma, M. L.; Sabharwal, Arun; Vohra, Neelam
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 1042 - 1044
