4-苯基噻吩-2-甲基羧酸盐合成路线 （共 10 条）
反应条件
sodium methylate in methanol 0.5 h; Ambient temperature; Yield given;
参考文献
Synthetic Communications, , vol. 24, # 12 p. 1721 - 1726
反应条件
1: conc. HCl / 0.25 h / 120 - 130 °C 2: NaOMe / methanol / 0.5 h / Ambient temperature View Scheme
参考文献
Synthetic Communications, , vol. 24, # 12 p. 1721 - 1726
反应条件
1: C2H5ONa / ethanol / 12 h / Ambient temperature 2: 1.) Conc. HCl, 2.) CH3ONa / 1.) 80 deg C, 15 min, 2.) CH3OH, reflux, 15 min. 3: 1.) 75percent H2SO4, NaNO2, 2.) 50percent aq. H3PO2 / 1.) H2O, 0 deg C, 30 min, 2.) 0 deg C, 30 min View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 19, p. 443 - 445
参考文献
Harris, Roger L.N.; McFadden, Helen G.
Australian Journal of Chemistry, 1986 , vol. 39, # 6 p. 887 - 892
反应条件
sulfuric acid; hypophosphorous acid; sodium nitrite 1.) H2O, 0 deg C, 30 min, 2.) 0 deg C, 30 min; Multistep reaction;
参考文献
Journal of Heterocyclic Chemistry, , vol. 19, p. 443 - 445
反应条件
in N,N-dimethyl-formamide 18 h; Heating;
参考文献
Tetrahedron Letters, , vol. 46, # 8 p. 1319 - 1320
反应条件
1: 1.) Conc. HCl, 2.) CH3ONa / 1.) 80 deg C, 15 min, 2.) CH3OH, reflux, 15 min. 2: 1.) 75percent H2SO4, NaNO2, 2.) 50percent aq. H3PO2 / 1.) H2O, 0 deg C, 30 min, 2.) 0 deg C, 30 min View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 19, p. 443 - 445
反应条件
1: 93 percent / aq. NaOH / methanol / Heating 2: 88 percent / Cu / quinoline / 1 h / Heating View Scheme
参考文献
Synthetic Communications, , vol. 24, # 12 p. 1721 - 1726
反应条件
1: 95 percent / LiAlH4 / diethyl ether / 1 h / Heating 2: 67 percent / pyridinumchlorochromate / CH2Cl2 / 2.5 h / Ambient temperature View Scheme
参考文献
Harris, Roger L.N.; McFadden, Helen G.
Australian Journal of Chemistry, 1986 , vol. 39, # 6 p. 887 - 892
反应条件
sodium hydroxide in methanol Heating;
参考文献
Synthetic Communications, , vol. 24, # 12 p. 1721 - 1726
