5-甲氧基-2-三氟甲基吡啶合成路线 （共 4 条）
反应条件
in N,N-dimethyl-formamide T=65°C; 2 h;
参考文献
Ekambome Bassene, Carine; Suzenet, Franck; Hennuyer, Nathalie; Staels, Bart; Caignard, Daniel-Henri; Dacquet, Catherine; Renard, Pierre; Guillaumet, Gerald
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 17 p. 4528 - 4532
反应条件
1: 95 percent / HI / 20 h / 100 - 170 °C 2: 87 percent / CuI; KF / dimethylformamide; 1-methyl-pyrrolidin-2-one / 16 h / 20 °C 3: 90 percent / dimethylformamide / 2 h / 65 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 17 p. 4528 - 4532
反应条件
1: 87 percent / CuI; KF / dimethylformamide; 1-methyl-pyrrolidin-2-one / 16 h / 20 °C 2: 90 percent / dimethylformamide / 2 h / 65 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 17 p. 4528 - 4532
反应条件
1.1: t-BuLi / tetrahydrofuran / -78 °C
1.2: 58 percent / tetrahydrofuran / 3 h / -78 °C
2.1: 65 percent / BuLi / tetrahydrofuran / 20 °C
3.1: 86 percent / H2 / Pd/C / methanol / 24 h / 20 °C / 750.06 Torr
4.1: 43 percent / BCl3; Bu4NI / CH2Cl2 / 24 h / -78 - 20 °C
View Scheme
参考文献
Ekambome Bassene, Carine; Suzenet, Franck; Hennuyer, Nathalie; Staels, Bart; Caignard, Daniel-Henri; Dacquet, Catherine; Renard, Pierre; Guillaumet, Gerald
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 17 p. 4528 - 4532
