N,N,2-三甲基丙酰胺合成路线 （共 43 条）
反应条件
(i) LiNEt2, HMPA, benzene, (ii) /BRN= 1209223/; Multistep reaction;
参考文献
Hullot,P. et al.
Canadian Journal of Chemistry, 1976 , vol. 54, p. 1098 - 1104
反应条件
(i) HCl, COCl2, CHCl3, (ii) Et3N; Multistep reaction;
参考文献
Bendall, Justin G.; Payne, Andrew N.; Screen, Thomas E. O.; Holmes, Andrew B.
Chemical Communications, 1997 , # 11 p. 1067 - 1068
反应条件
1: N,N-dimethyl-2-methylpropionamide With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=0°C; 0.5 h; 2: chloro-trimethyl-silane in tetrahydrofuran; hexane T=0 - 20°C; Further stages.;
参考文献
Nishimoto, Yoshihiro; Yasuda, Makoto; Baba, Akio
Organic Letters, 2007 , vol. 9, # 24 p. 4931 - 4934
反应条件
diethyl ether; LiAlH2(OEt)2
参考文献
Brown; Tsukamoto
Journal of the American Chemical Society, 1959 , vol. 81, p. 502
反应条件
(i) COCl2, CH2Cl2, (ii) Py-N-oxide, Et3N; Multistep reaction;
参考文献
Da Costa,R. et al.
Journal of the American Chemical Society, 1979 , vol. 101, p. 4381 - 4383
反应条件
1: N,N-dimethyl-2-methylpropionamide With PhMe2SiLi in tetrahydrofuran
T=-78°C; 1 h;
2: phenyllithium in tetrahydrofuran
T=-20°C; 1 h;
参考文献
Buswell, Marina; Fleming, Ian; Ghosh, Usha; Mack, Stephen; Russell, Matthew; Clark, Barry P.
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 20 p. 3006 - 3017
反应条件
1: N,N-dimethyl-2-methylpropionamide With PhMe2SiLi in tetrahydrofuran
T=-78°C; 1 h;
2: phenyllithium in tetrahydrofuran
T=-20°C; 1 h;
3: chloroformic acid ethyl ester in tetrahydrofuran
参考文献
Buswell, Marina; Fleming, Ian; Ghosh, Usha; Mack, Stephen; Russell, Matthew; Clark, Barry P.
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 20 p. 3006 - 3017
反应条件
DEANB/5 mol SpiroCAT formulation in tetrahydrofuran
T=20°C; 3.3 h;
参考文献
Coleridge, Brian M.; Angert, Thomas P.; Marks, Lucas R.; Hamilton, Patrick N.; Sutton, Christopher P.; Matos, Karl; Burkhardt, Elizabeth R.
Tetrahedron Letters, 2010 , vol. 51, # 46 p. 5973 - 5976
反应条件
triethylammonium tetrakis(pentafluorophenyl)-borate; diethylesilane; (2,6-bis(di-tert-butylphosphinito)phenyl)Ir(H)(SiEt2H); (2,6-bis(di-tert-butylphosphinito)phenyl)Ir(H)3(SiEt2H); hydrogen in benzene-d6
T=60°C; P=760.051 Torr; 0.4 h;
参考文献
Park, Sehoon; Brookhart, Maurice
Journal of the American Chemical Society, 2012 , vol. 134, # 1 p. 640 - 653
反应条件
(COBr)2; triethylamine
1.) CH2Cl2, 0 deg C, 2 h, 2.) r.t., 2 h; Yield given. Multistep reaction;
参考文献
TSRL, INC.; HILFINGER, John; SHEN, Wei
Patent: WO2011/123856 A1, 2011 ;
Location in patent: Page/Page column 36 ;
WO 2011/123856 A1
