3-(2-甲基-5-吡啶基)-3-氧代丙酸乙酯合成路线 （共 12 条）
反应条件
lithium hexamethyldisilazane in tetrahydrofuran T=-50°C; 0.5 h;
参考文献
Sivagurunathan; Raja Mohamed Kamil; Syed Shafi; Liakth Ali Khan; Ragavan, R. Venkat
Tetrahedron Letters, 2011 , vol. 52, # 11 p. 1205 - 1207
反应条件
sodium hydroxide; acetic anhydride; acetic acid; palladium on activated carbon in methanol; dichloromethane; water; toluene
参考文献
Lonza Ltd.
Patent: US4687856 A1, 1987 ;
反应条件
sodium hydride in N,N-dimethyl-formamide T=80°C; 3 h;
参考文献
THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM; RICE UNIVERSITY
Patent: WO2008/70350 A2, 2008 ;
Location in patent: Page/Page column 40-41 ;
反应条件
1: 10percent aq. H2SO4 / 2 h / Heating 2: 92 percent / pTsOH / toluene / 8 h / Heating View Scheme
参考文献
Tanis, Steven P.; Parker, Timothy T.; Colca, Jerry R.; Fisher, Roberta M.; Kletzein, Rolf F.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 26 p. 5053 - 5063
反应条件
1: 10percent aq. H2SO4 / 2 h / Heating 2: 92 percent / pTsOH / toluene / 8 h / Heating 3: 24 percent / H2O / 5 h / 150 °C View Scheme
参考文献
Tanis, Steven P.; Parker, Timothy T.; Colca, Jerry R.; Fisher, Roberta M.; Kletzein, Rolf F.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 26 p. 5053 - 5063
反应条件
sulfuric acid 2 h; Heating; Yield given;
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 26 p. 5053 - 5063
反应条件
1: 10percent aq. H2SO4 / 2 h / Heating 2: 90 percent / NaBH4 / ethanol / 1.5 h / 0 °C View Scheme
参考文献
Tanis, Steven P.; Parker, Timothy T.; Colca, Jerry R.; Fisher, Roberta M.; Kletzein, Rolf F.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 26 p. 5053 - 5063
反应条件
1: 10percent aq. H2SO4 / 2 h / Heating 2: 90 percent / NaBH4 / ethanol / 1.5 h / 0 °C 3: 1.) NaH / 1.) hexane, DMF, 0 deg C, 1.5 h, 2.) hexane, DMF, from -78 deg C to RT 4: 27 percent / H2O / 5 h / 160 °C 5: 62 percent / diethyl azodicarboxylate, Ph3P / tetrahydrofuran / 18 h / Ambient temperature 6: 58 percent / piperidine / ethanol / 18 h / Heating 7: 61 percent / NaBH4, 1.0N aq. NaOH, CoCl2*6H2O, 2,2'-dipyridyl / dimethylformamide / 42 h / Ambient temperature 8: 98 percent / 2N aq. HCl / methanol / 2 h / Heating View Scheme
参考文献
Tanis, Steven P.; Parker, Timothy T.; Colca, Jerry R.; Fisher, Roberta M.; Kletzein, Rolf F.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 26 p. 5053 - 5063
反应条件
1: 10percent aq. H2SO4 / 2 h / Heating 2: 92 percent / pTsOH / toluene / 8 h / Heating 3: 24 percent / H2O / 5 h / 150 °C 4: 55 percent / diethyl azodicarboxylate, Ph3P / tetrahydrofuran / 18 h / Ambient temperature View Scheme
参考文献
Tanis, Steven P.; Parker, Timothy T.; Colca, Jerry R.; Fisher, Roberta M.; Kletzein, Rolf F.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 26 p. 5053 - 5063
反应条件
1: 10percent aq. H2SO4 / 2 h / Heating 2: 92 percent / pTsOH / toluene / 8 h / Heating 3: 24 percent / H2O / 5 h / 150 °C 4: 55 percent / diethyl azodicarboxylate, Ph3P / tetrahydrofuran / 18 h / Ambient temperature 5: 56 percent / piperidine / ethanol / 18 h / Heating 6: 96 percent / NaBH4, 1.0N aq. NaOH, CoCl2*6H2O, dimethylglyoxime / dimethylformamide; tetrahydrofuran / 18 h / Ambient temperature View Scheme
参考文献
Tanis, Steven P.; Parker, Timothy T.; Colca, Jerry R.; Fisher, Roberta M.; Kletzein, Rolf F.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 26 p. 5053 - 5063
