5-(4-吡啶基)-2-噻吩羧酸合成路线 （共 4 条）
反应条件
caesium carbonate; tetrakis(triphenylphosphine) palladium(0) in DMF (N,N-dimethyl-formamide); ethanol; water T=150°C; 0.166667 h;
参考文献
WO2004/13130 A1, ;
Page 173 ;
反应条件
1: With sodium hydroxide; water in ethanol T=20°C; 16 h; 2: With hydrogenchloride in water pH=3 - 4;
参考文献
WO2005/95386 A1, ;
Page/Page column 124-125 ;
反应条件
sodium carbonate; bis-triphenylphosphine-palladium(II) chloride in ethylene glycol dimethyl ether; water Suzuki Coupling; 72 h; Heating / reflux;
参考文献
US2008/293716 A1, ;
Page/Page column 14 ;
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in acetonitrile T=80°C; Suzuki coupling; 3 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 2 p. 363 - 369
