(S)-(-)-甲基丁二酸合成路线 （共 34 条）
反应条件
BPPM-Rh; hydrogen; triethylamine in methanol T=20°C; P=15200 Torr; 20 h;
参考文献
Achiwa, K.
Heterocycles, 1981 , vol. 15, # 2 p. 1023 - 1026
反应条件
hydrogen; triethylamine; Ru2Cl4((R)-(+)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl)2 in tetrahydrofuran; toluene T=35°C; P=2206.5 Torr; 24 h; op = 88percent, var. cat.; RuHCl*<(+)-BINAP>2; Title compound not separated from byproducts;
参考文献
Yamashita, Mitsuji; Kobayashi, Mineaki; Sugiura, Motoyuki; Tsunekawa, Kenji; Oshikawa, Tatsuo; et al.
Bulletin of the Chemical Society of Japan, 1986 , vol. 59, # 1 p. 175 - 178
反应条件
formic acid; [3H]-Tetracycline; 1,1'-dimethyl-4,4'-bipyridinium dichloride in water T=45°C; 30 h; Clostridium formicoaceticum;
参考文献
Eck, Richard; Simon, Helmut
Tetrahedron, 1994 , vol. 50, # 48 p. 13631 - 13640
反应条件
formaldehyd; [3H]-Tetracycline; 1,1'-dimethyl-4,4'-bipyridinium dichloride in water T=37°C; 69 h; Clostridium formicoaceticum, phosphate buffer;
参考文献
Tetrahedron, , vol. 50, # 48 p. 13641 - 13654
反应条件
hydrogen; chiral iridium phosphorothioite on silica in dichloromethane T=40°C; P=15001.5 Torr; Title compound not separated from byproducts.;
参考文献
Journal of Catalysis, , vol. 254, # 1 p. 91 - 100
反应条件
trifluoroacetic acid
参考文献
Davies, Stephen G.; Dixon, Darren J.
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 17 p. 2635 - 2643
反应条件
1: With 1,8-diazabicyclo[5.4.0]undec-7-ene in methanol T=0°C; 0.5 h; 2: With acetic anhydride; acetic acid; sodium nitrite T=0 - 20°C; 18 h; 3: With water; dihydrogen peroxide; lithium hydroxide hydrate in tetrahydrofuran T=0°C; 4 h; optical yield given as percent ee;
参考文献
Uraguchi, Daisuke; Ueki, Yusuke; Ooi, Takashi
Science, 2009 , vol. 326, # 5949 p. 120 - 123
反应条件
hydrogen; triethylamine; lt;Rh(cod)lt;2S,4S-2-(CH2-PPh2)-4-PPh2-pyrrolidine-1-COOtBugt;BF4 in methanol; benzene T=20°C; P=15200 Torr; 20 h; effects of added Et3N on stereoselectivity; Product distributionMechanism;
参考文献
Journal of Organic Chemistry, , vol. 45, # 23 p. 4728 - 4739
反应条件
sodium hydroxide in methanol; tert-butyl alcohol 24 h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of the American Chemical Society, , vol. 119, # 28 p. 6496 - 6511
参考文献
Chemistry Letters, , # 5 p. 397 - 398
